Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence

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	Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence
	Li, Man 1; Du, Wei 1; Shao, Feng 1; Wang, Weiwen2
刊名	BEHAVIOURAL BRAIN RESEARCH
	2016-10-15
通讯作者邮箱	shaof@pku.edu.cn ; wangww@psych.ac.cn
卷号	313 期号:0 页码:177-183
关键词	Social isolation Cognitive behaviour Brain-derived neurotrophic factor (BDNF) Epigenetics
ISSN号	0166-4328
通讯作者	Shao, Feng ; Wang, Weiwen
英文摘要	Early life adversity, such as social isolation, causes a variety of changes to the development of cognitive abilities and the nervous system. Increasing evidence has shown that epigenetic modifications mediate gene-environment interactions throughout the lifespan. In this study, we investigated the effect of adolescent social isolation on cognitive behaviours and epigenetic alterations of the brain-derived neurotrophic factor (BDNF) gene. Male Sprague Dawley rats were randomly assigned to either group reared or isolation-reared conditions during post-natal days (PNDs) 21-34. On PND 56, all rats underwent behavioural testing and were then sacrificed for biochemical testing. Adolescent social isolation induced impaired PPI. Regarding BDNF, the isolation-reared rats demonstrated increased BDNF mRNA levels, H3 acetylation at the BDNF gene and BDNF protein expression in the medial prefrontal cortex (mPFC). In contrast, the BDNF mRNA levels, H3 acetylation of the BDNF gene and BDNF protein expression were decreased in the hippocampus of the isolation-reared rats. The present study indicated that epigenetic regulation of BDNF may be one of the molecular mechanisms that mediated the cognitive dysfunction. Moreover, the interaction between the mPFC and hippocampus might play an important role in the regulation of cognitive behaviour. (C) 2016 Elsevier B.V. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]	MEDIAL PREFRONTAL CORTEX ; NEUROTROPHIC FACTOR EXPRESSION ; SPATIAL MEMORY PERFORMANCE ; ACOUSTIC STARTLE RESPONSE ; PREPULSE INHIBITION ; ADULT RATS ; MATERNAL SEPARATION ; VENTRAL HIPPOCAMPUS ; THETA-OSCILLATIONS ; NUCLEUS-ACCUMBENS
收录类别	SCI
语种	英语
WOS记录号	WOS:000382413800021
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/20535]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Peking Univ, Beijing Key Lab Behav & Mental Hlth, Sch Psychol & Cognit Sci, 5 Yiheyuan Rd, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Li, Man,Du, Wei,Shao, Feng,et al. Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence[J]. BEHAVIOURAL BRAIN RESEARCH,2016,313(0):177-183.
APA	Li, Man,Du, Wei,Shao, Feng,&Wang, Weiwen.(2016).Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence.BEHAVIOURAL BRAIN RESEARCH,313(0),177-183.
MLA	Li, Man,et al."Cognitive dysfunction and epigenetic alterations of the BDNF gene are induced by social isolation during early adolescence".BEHAVIOURAL BRAIN RESEARCH 313.0(2016):177-183.