GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE
	Wu, Junfang 1; Fu, Bin 2; Lei, Hehua 1; Tang, Huiru 1,3; Wang, Yulan 1,4
刊名	NEUROSCIENCE
	2016-09-22
卷号	332 页码:160-169
关键词	Alzheimer's disease gender difference metabonomics peripheral liver extracts fatty acids
英文摘要	Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive impairment. Currently, there is less knowledge of the involvement of the peripheral biofluid/organ in AD, compared with the central nervous system. In addition, with reported high morbidity in women in particular, it has become very important to explore whether gender difference in the peripheral metabolome is associated with AD. Here, we investigated metabolic responses of both plasma and liver tissues using an APP/PS1 double mutant transgenic mouse model with NMR spectroscopy, as well as analysis from serum biochemistry and histological staining. Fatty acid composition from plasma and liver extracts was analyzed using GC-FID/MS. We found clear gender differences in AD transgenic mice when compared with their wild-type counterparts. Female AD mice displayed more intensive responses, which were highlighted by higher levels of lipids, 3-hydroxybutyrate and nucleotide related metabolites, together with lower levels of glucose. These observations indicate that AD induces oxidative stress and impairs cellular energy metabolism in peripheral organs. Disturbances in AD male mice were milder with depletion of monounsaturated fatty acids. We also observed a higher activity of delta-6-desaturate and suppressed activity of delta-5-desaturate in female mice, whereas inhibited stearoyl-CoA-desaturase in male mice suggested that AD induced by the double mutant genes results in different fatty acids catabolism depending on gender. Our results provide metabolic clues into the peripheral biofluid/organs involved in AD, and we propose that a gender-specific scheme for AD treatment in men and women may be required. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	ESTIMATED DESATURASE ACTIVITIES ; FATTY-ACID-COMPOSITION ; AMYLOID PRECURSOR PROTEIN ; ALZHEIMERS-DISEASE ; SEX-DIFFERENCES ; COGNITIVE IMPAIRMENT ; PREFRONTAL CORTEX ; NMR-SPECTROSCOPY ; OXIDATIVE DAMAGE ; BIPOLAR DISORDER
收录类别	SCI
语种	英语
WOS记录号	WOS:000381329800014
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9504]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, CAS Key Lab Magnet Resonance Biol Syst, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China 2.Hubei Prov Hosp Integrated Chinese & Western Med, Dept Neurol, Wuhan 430015, Peoples R China 3.Fudan Univ, Collaborat Innovat Ctr Genet & Dev, State Key Lab Genet Engn,Metabon & Syst Biol Lab, Minist Educ,Key Lab Contemporary Anthropol,Sch Li, Shanghai 200438, Peoples R China 4.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Wu, Junfang,Fu, Bin,Lei, Hehua,et al. GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE[J]. NEUROSCIENCE,2016,332:160-169.
APA	Wu, Junfang,Fu, Bin,Lei, Hehua,Tang, Huiru,&Wang, Yulan.(2016).GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE.NEUROSCIENCE,332,160-169.
MLA	Wu, Junfang,et al."GENDER DIFFERENCES OF PERIPHERAL PLASMA AND LIVER METABOLIC PROFILING IN APP/PS1 TRANSGENIC AD MICE".NEUROSCIENCE 332(2016):160-169.