Microplastic Size-Dependent Toxicity, Oxidative Stress Induction, and p-JNK and p-p38 Activation in the Monogonont Rotifer (Brachionus koreanus)

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	Microplastic Size-Dependent Toxicity, Oxidative Stress Induction, and p-JNK and p-p38 Activation in the Monogonont Rotifer (Brachionus koreanus)
	Jeong, Chang-Bum 1,2; Won, Eun-Ji 1,3; Kang, Hye-Min 1; Lee, Min-Chul 1; Hwang, Dae-Sik 1; Hwang, Un-Ki 4; Zhou, Bingsheng 5; Souissi, Sami 6; Lee, Su-Jae 7; Lee, Jae-Seong 1
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2016-08-16
卷号	50 期号:16 页码:8849-8857
ISSN号	0013-936X
英文摘要	In this study, we evaluated accumulation and adverse effects of ingestion of microplastics in the monogonont rotifer (Brachionus koreanus). The dependence of microplastic toxicity on particle size-was investigated by measuring several in vivo end points and studying the ingestion and egestion using 0.05-, 0.5-, and 6-mu m nonfunctionalized polystyrene microbeads. To identify the defense mechanisms activated in response to microplastic exposure, the activities of several antioxidant-related enzymes and the phosphorylation status of mitogen-activated protein kinases (MAPKs) were determined. Exposure to polystyrene microbeads of all sizes led to significant size dependent effects, including reduced groWth rate, reduced fecundity, decreased lifespan and longer reproduction time. Rotifers exposed to 6-mu m fluorescently labeled microbeads exhibited almost no fluorescence after 24 h, while rotifers exposed to 0.05- and 0.5-mu m fluoresceatly labeled inicrobeads displayed fluorescence until 48 h, suggesting that 6-mu m microbeads are more effectively egested from B. koreanus than 0.05- or 0.5-mu m microbeads. This observation provides a potential explanation for our findings that microbead toxicity was size dependent and smaller microbeads were more toxic. In vitro tests revealed that antioxidant-related enzymes and MAPK signaling pathways were significantly activated in response to microplastic exposure in a size-dependent manner.
WOS标题词	Science & Technology ; Technology ; Life Sciences & Biomedicine
类目[WOS]	Engineering, Environmental ; Environmental Sciences
研究领域[WOS]	Engineering ; Environmental Sciences & Ecology
关键词[WOS]	COPEPOD TIGRIOPUS-JAPONICUS ; MYTILUS-EDULIS L. ; MARINE-ENVIRONMENT ; SIGNALING PATHWAY ; GROWTH-RETARDATION ; NANOPARTICLES ; FECUNDITY ; MUSSEL ; CELLS ; ECOTOXICOLOGY
收录类别	SCI
语种	英语
WOS记录号	WOS:000381654600048
内容类型	期刊论文
源URL	[http://ir.ihb.ac.cn/handle/342005/28336]
专题	水生生物研究所_藻类生物学及应用研究中心_学位论文
作者单位	1.Sungkyunkwan Univ, Coll Sci, Dept Biol Sci, Suwon 16419, South Korea 2.Hanyang Univ, Dept Chem, Coll Nat Sci, Seoul 04763, South Korea 3.Korea Inst Ocean Sci & Technol, Marine Chem & Geochem Res Ctr, Ansan 15627, South Korea 4.Natl Fisheries Res & Dev Inst, Marine Ecol Risk Assessment Ctr, West Sea Fisheries Res Inst, Inchon 46083, South Korea 5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 6.Univ Littoral Cote dOpale, LOG, Univ Lille, CNRS,UMR 8187, F-62930 Wimereux, France 7.Hanyang Univ, Dept Life Sci, Coll Nat Sci, Seoul 04763, South Korea
推荐引用方式 GB/T 7714	Jeong, Chang-Bum,Won, Eun-Ji,Kang, Hye-Min,et al. Microplastic Size-Dependent Toxicity, Oxidative Stress Induction, and p-JNK and p-p38 Activation in the Monogonont Rotifer (Brachionus koreanus)[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2016,50(16):8849-8857.
APA	Jeong, Chang-Bum.,Won, Eun-Ji.,Kang, Hye-Min.,Lee, Min-Chul.,Hwang, Dae-Sik.,...&Lee, Jae-Seong.(2016).Microplastic Size-Dependent Toxicity, Oxidative Stress Induction, and p-JNK and p-p38 Activation in the Monogonont Rotifer (Brachionus koreanus).ENVIRONMENTAL SCIENCE & TECHNOLOGY,50(16),8849-8857.
MLA	Jeong, Chang-Bum,et al."Microplastic Size-Dependent Toxicity, Oxidative Stress Induction, and p-JNK and p-p38 Activation in the Monogonont Rotifer (Brachionus koreanus)".ENVIRONMENTAL SCIENCE & TECHNOLOGY 50.16(2016):8849-8857.