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题名	磁性药物靶向定位的研究; 磁性药物靶向定位的研究
作者	1徐华,电工研究所
学位类别	硕士
答辩日期	2004
授予单位	中国科学院电工研究所
导师	1宋涛,电工研究所
关键词	磁性药物靶向治疗 磁流体 磁力 磁共振成像 Magnetic drug targeting ferrofluids MRI magnetic force
其他题名	磁性药物靶向定位的研究
学位专业	电机与电器
中文摘要	磁性药物靶向治疗是利用磁场使具有磁响应的药物聚集在靶部位，提高靶部位药物的浓度，降低药物对正常组织的毒性和副作用的一种治疗方法。本文主要通过磁体设计和作为药物载体的磁流体的体内外实验，研究在磁性药物靶向治疗中影响磁性药物在靶部位滞留的主要因素及其在动物体内的靶向性。根据三维有限元（FEA）电磁场计算软件仿真和计算，自制出实验所需的产生高梯度磁场的永磁磁体。体外模拟人体血管系统，检测影响磁流体滞留的主要因素，实验结果表明磁流体在靶部位的滞留率主要和载液的流速、外加磁场强度和梯度有关。简化磁粒受力模型，理论上研究磁流体的流体动力学，针对体外实验模型，建立了外磁场作用下铁磁流体在靶部位的滞留率的理论计算方法，与实验结果基本吻合。实验还发现当铁磁流体浓度较高时磁颗粒发生团聚，因此不能简单的用单一的磁颗粒来计算滞留情况，由此解释了磁纳米在磁场作用下的聚集原因。在国内率先采用磁共振成像（MRI）技术研究作为药物载体的磁流体的体内靶向性。动物实验中，将大鼠右肾置于磁体中，经股静脉注射磁流体，利用磁流体是超顺磁性材料的特性，通过磁共振成像技术检测磁流体在大鼠右肾的分布。实验结果表明MRI技术是检测磁性药物在靶部位聚集的一种有效方法，在外磁场作用后，大鼠右肾部位的信号强度大大减小，有很高的磁流体浓度在右肾部位。通过以上实验和研究表明，采用磁流体作为药物的载体，在外磁场作用下可实现靶向可控，提高药物在靶部位的治疗效果。 Magnetic drug targeting was aimed at concentrating magnetic drugs at a defined target site with the aid of magnetic field, and enhanced drug concentration in the target and at the same time reduced the toxicity and side effects to normal tissues. The article focused on studying the main factor of affecting the retention of magnetic drug in vitro and the target of magnetic drug in vivo by the ferrofiuids as drug carriers. The magnet which generated the high magnetic field gradient was developed by the FEA electromagnetic computing software. An in vitro analogy of the human circulatory was used to test the main factor of affecting the retention of ferrofluid. The results showed the retention of ferrofiuids was related to the flow rate of medium, the magnitude of magnetic field and magnetic field gradient. The hydrodynamics of ferrofiuids as drug carriers was theoretically studied by the simplified model of forces exerted on ferrofiuids. For the experimental model in vitro, a method for calculating the retention of ferrofiuids on the outside magnetic fields was set up. The results showed the calculation results coincided with experimental results in general. It was also found that the magnetic particles aggregated when high concentration of ferrofiuids were injected, so the retention of ferrofiuids can not be calculated by the single particle. It gives a possible explanation of aggregation of magnetic nanoparticles within magnetic field. The target of ferrofiuids as drug carrier was researched by the MRI in vivo. The magnet was attached near the right kidney of rats, the ferrofiuids were injected by the femoral vein, for the superparamagnetic characteristics of ferrofiuids, we found total signal loss of kidney by MRI after focusing by means of the magnetic field. The result showed that the ferrofiuids concentration in the targeted right kidney was enhanced by the external the magnetic field. These previous experimental results in vitro and in vivo using magnetic drug targeting was encouraging and should be confirmed in further studies. The principle of magnetic drug targeting opened an interesting perspective in oncology.
语种	中文
公开日期	2010-10-18
页码	67
内容类型	学位论文
源URL	[http://ir.iee.ac.cn/handle/311042/7331]
专题	电工研究所_其他部门_其他部门_硕士学位论文
推荐引用方式 GB/T 7714	1徐华,电工研究所. 磁性药物靶向定位的研究, 磁性药物靶向定位的研究[D]. 中国科学院电工研究所. 2004.

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