INFANTILE SPASMS - A RETROSPECTIVE STUDY OF 105 CASES

	INFANTILE SPASMS - A RETROSPECTIVE STUDY OF 105 CASES
	FENG, YK; LIU, XQ; Sha Y(沙因); Liu PS(刘平生); SHA, Y; LIU, PS
刊名	CHINESE MEDICAL JOURNAL
	1991
卷号	104 期号:5 页码:416-421
通讯作者	CHINESE ACAD SCI,INST HIGH ENERGY PHYS,BEIJING 100039,PEOPLES R CHINA
英文摘要	This paper is a summary of our observations on 105 cases of infantile spasms. The age of onset was around six months after birth, but the patients came for treatment mainly about one year after onset. Fever of unknown cause, asphyxia, birth injury, infection of the central nervous system, tuberous sclerosis, phenylketonuria and recent immunization etc. were complained. Clinically, it is characterized by head nodding, mental retardation, myclonic jerks and various neurologic deficits. EEG findings showed classical or modified arrythmia or other epileptiform patterns. About one third of 22 cases examined had abnormal brain stem auditory evoked potentials. Among 42 patients who underwent CT scanning before ACTH treatment, 18 were normal and 7 abnormal; during ACTH treatment 3 normal and 4 abnormal; after completion of treatment, 4 normal and 6 abnormal, suggesting no further atrophy of the brain. Examination of trace elements of the hair by particle-induced X-ray emission (PIXE) method in 23 patients revealed a significant difference in lead, calcium and zinc contents between patients and 101 controls, but no statistical difference in iron and copper contents between the two groups. Sodium valproate, prednisone and ACTH appear to be effective in the treatment of infantile spasms. Eight patients fully recovered, and they can go to school without difficulty. Many patients derived various degrees of improvement to the satisfaction of their parents. Two patients were still amented and often attacked by myoclonus. The effects, side effects of these drugs, and the possible pathogenesis were discussed.
学科主题	General & Internal Medicine
类目[WOS]	Medicine, General & Internal
研究领域[WOS]	General & Internal Medicine
原文出处	SCI
语种	英语
WOS记录号	WOS:A1991FN30500014
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/237386]
专题	高能物理研究所_多学科研究中心
作者单位	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	FENG, YK,LIU, XQ,Sha Y,et al. INFANTILE SPASMS - A RETROSPECTIVE STUDY OF 105 CASES[J]. CHINESE MEDICAL JOURNAL,1991,104(5):416-421.
APA	FENG, YK,LIU, XQ,沙因,刘平生,SHA, Y,&LIU, PS.(1991).INFANTILE SPASMS - A RETROSPECTIVE STUDY OF 105 CASES.CHINESE MEDICAL JOURNAL,104(5),416-421.
MLA	FENG, YK,et al."INFANTILE SPASMS - A RETROSPECTIVE STUDY OF 105 CASES".CHINESE MEDICAL JOURNAL 104.5(1991):416-421.