Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate

	Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate
	Sun,Tingting; Guan,Xingang; Zheng,Min; Jing,Xiabin; Xie,Zhigang
刊名	acs medicinal chemistry letters
	2015
卷号	6 期号:4 页码:430-433
关键词	SQUAMOUS-CELL CARCINOMA CISPLATIN RESISTANCE CANCER-CELLS TUMOR-CELLS DRUG DNA CHEMORESISTANCE DELIVERY ASPIRIN AGENTS
通讯作者	xie,zg
英文摘要	a convenient synthesis of a bodipy (1,3,5,7-tetramethyl-8-(4-pyridyl)-4,4'-difluoroboradiazaindacene) labeled platinum compound (bodipy-pt) was developed by direct conjugation of cisplatin with the pyridine group of bodipy. the membrane permeability and selective uptake of bodipy-pt in the mitochondria was studied using confocal laser scanning microscopy (clsm). the fluorescent bodipy-pt conjugate showed high cellular proliferation inhibition against human cervical carcinoma (hela) and human breast cancer (mcf-7) cells, with half maximal inhibitory concentrations (ic50) of 27.37 and 12.14 mu m, respectively. this work highlights the potential of using bodipy labeled pt compounds to realize the visualization of pt distribution in living cells.
收录类别	SCI
语种	英语
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67929]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Sun,Tingting,Guan,Xingang,Zheng,Min,et al. Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate[J]. acs medicinal chemistry letters,2015,6(4):430-433.
APA	Sun,Tingting,Guan,Xingang,Zheng,Min,Jing,Xiabin,&Xie,Zhigang.(2015).Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate.acs medicinal chemistry letters,6(4),430-433.
MLA	Sun,Tingting,et al."Mitochondria-Localized Fluorescent BODIPY-Platinum Conjugate".acs medicinal chemistry letters 6.4(2015):430-433.