Overcoming tumor resistance to cisplatin through micelle-mediated combination chemotherapy

	Overcoming tumor resistance to cisplatin through micelle-mediated combination chemotherapy
	Zhou,Dongfang; Cong,Yuwei; Qi,Yanxin; He,Shasha; Xiong,Hejian; Wu,Yanjuan; Xie,Zhigang; Chen,Xuesi; Jing,Xiabin; Huang,Yubin
刊名	biomaterials science
	2015
卷号	3 期号:1 页码:182-191
关键词	PLATINUM ANTICANCER DRUGS IN-VIVO DNA-REPAIR DELIVERY COMPLEXES NANOPARTICLES MECHANISMS PRODRUG DESIGN GLUTATHIONE
通讯作者	huang,yb
英文摘要	the main obstacles to cancer therapy are the inability to target cancer cells and the acquired drug resistance after a period of chemotherapy. reduced drug uptake and dna repair are the two main mechanisms involved in cisplatin resistance. in the present investigation, canthaplatin, a pt(iv) pro-drug of cisplatin and a protein phosphatase 2a (pp2a) inhibitor (4-(3-carboxy-7-oxa-bicyclo[2.2.1]heptane-2-carbonyl)piperazine-1-carboxylic acid tert-butyl ester), was designed and delivered using peg-b-plga micelles for combination chemotherapy. polymer/canthaplatin micelles facilitated the delivery of the drug into cancer cells through endocytosis and diminished dna repair by pp2a inhibition, resulting in enhanced anti-tumor efficiency and excellent reversal ability of tumor resistance to cisplatin both in vitro and in vivo. additionally, the polymer/canthaplatin micelles could prolong drug residence in the blood and decrease the side effects when compared to cisplatin.
收录类别	SCI
语种	英语
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/67871]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhou,Dongfang,Cong,Yuwei,Qi,Yanxin,et al. Overcoming tumor resistance to cisplatin through micelle-mediated combination chemotherapy[J]. biomaterials science,2015,3(1):182-191.
APA	Zhou,Dongfang.,Cong,Yuwei.,Qi,Yanxin.,He,Shasha.,Xiong,Hejian.,...&Huang,Yubin.(2015).Overcoming tumor resistance to cisplatin through micelle-mediated combination chemotherapy.biomaterials science,3(1),182-191.
MLA	Zhou,Dongfang,et al."Overcoming tumor resistance to cisplatin through micelle-mediated combination chemotherapy".biomaterials science 3.1(2015):182-191.