One-step synthesized immunostimulatory oligonucleotides-functionalized quantum dots for simultaneous enhanced immunogenicity and cell imaging

	One-step synthesized immunostimulatory oligonucleotides-functionalized quantum dots for simultaneous enhanced immunogenicity and cell imaging
	Tao,Yu; Zhang,Yan; Ju,Enguo; Ren,Jinsong; Qu,Xiaogang
刊名	colloids and surfaces b-biointerfaces
	2015
卷号	126 期号:7 页码:585-589
关键词	SEMICONDUCTOR NANOCRYSTALS INTRACELLULAR DELIVERY CPG MOTIFS IN-VIVO DNA NANOPARTICLES NANOSTRUCTURES ACTIVATION ADJUVANTS DESIGN
通讯作者	ren,js
英文摘要	unmethylated cytosine phosphate guanine (cpg) dinucleotides, normally occur in natural bacterial and viral genomes, show strong immunostimulatory activities to invading pathogens and have found widespread applications in both basic research and clinical trials. for the first time, we design a simple one-step synthesis of cpg-functionalized quantum dots (qds), combining fascinating features of enhanced immunogenicity and cell imaging. the induction of qds can greatly increase cpg uptake ability by tlr9-positive cells and elevate cpg stability against nuclease degradation. what is more, the outstanding optical properties also suggest that the cpg-qds can serve as promising optical probes for the evaluation of the cellular uptake efficiency of the cpg motifs. to our best knowledge, this is the first report to use a facile one-pot synthesis strategy that allows the cpg-functionalized qds to be prepared, which are able to serve as both the potent platform for immunotherapy and the fluorescent probes for intracellular imaging. (c) 2014 elsevier b.v. all rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000350918900076
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/65176]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Tao,Yu,Zhang,Yan,Ju,Enguo,et al. One-step synthesized immunostimulatory oligonucleotides-functionalized quantum dots for simultaneous enhanced immunogenicity and cell imaging[J]. colloids and surfaces b-biointerfaces,2015,126(7):585-589.
APA	Tao,Yu,Zhang,Yan,Ju,Enguo,Ren,Jinsong,&Qu,Xiaogang.(2015).One-step synthesized immunostimulatory oligonucleotides-functionalized quantum dots for simultaneous enhanced immunogenicity and cell imaging.colloids and surfaces b-biointerfaces,126(7),585-589.
MLA	Tao,Yu,et al."One-step synthesized immunostimulatory oligonucleotides-functionalized quantum dots for simultaneous enhanced immunogenicity and cell imaging".colloids and surfaces b-biointerfaces 126.7(2015):585-589.