Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery

	Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery
	Li,Wenhai; Guan,Xingang; Sun,Tingting; Huang,Yubin; Jing,Xiabin; Xie,Zhigang
刊名	colloids and surfaces b-biointerfaces
	2015
卷号	126 期号:7 页码:217-223
关键词	FACILE SYNTHESIS BLOCK-COPOLYMER MICELLES CURCUMIN POLYMERS RELEASE PH NANOPARTICLES CANCER
通讯作者	xie,zg
英文摘要	one-step synthesis of amphiphilic polymers containing disulfide bond within the hydrophobic backbone was demonstrated via multi-component passerini reaction. the obtained polymer was self-assembled into micelles in aqueous solution. curcumin (cur), an effective and safe anticancer agent, which was limited by its water insolubility and poor bioavailability, was loaded into the micelles as a model drug. the nanoscale polymeric micelles were confirmed by dynamic light scattering (dls) and transmission electron microscopy (tem). faster intracellular cur release was observed by confocal laser scanning microscopy (clsm) in the hela cells pretreated with gsh than in the unpretreated ones. micelles also loaded with nh2-bodipy which was almost non-fluorescent and gave strong enhanced fluorescence under acid conditions. the phenomenon of the stronger enhanced fluorescence in the pretreated hela cells showed further that the obtained polymer was reduction-sensitive. in vitro mtt assays showed that the micelles were biocompatible and cur-loaded micelles had higher cellular proliferation inhibition in contrast to free cur toward hela cells. these results highlight the potential of using multi-component passerini reaction to make functional copolymers as smart nanocarriers for drug delivery. (c) 2014 elsevier b.v. all rights reserved.
收录类别	SCI
语种	英语
WOS记录号	WOS:000350918900027
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/65174]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Li,Wenhai,Guan,Xingang,Sun,Tingting,et al. Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery[J]. colloids and surfaces b-biointerfaces,2015,126(7):217-223.
APA	Li,Wenhai,Guan,Xingang,Sun,Tingting,Huang,Yubin,Jing,Xiabin,&Xie,Zhigang.(2015).Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery.colloids and surfaces b-biointerfaces,126(7),217-223.
MLA	Li,Wenhai,et al."Reduction-sensitive amphiphilic copolymers made via multi-component Passerini reaction for drug delivery".colloids and surfaces b-biointerfaces 126.7(2015):217-223.