A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release

	A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release
	He,Shasha; Cong,Yuwei; Zhou,Dongfang; Li,Jizhen; Xie,Zhigang; Chen,Xuesi; Jing,Xiabin; Huang,Yubin
刊名	journal of materials chemistry b
	2015
卷号	3 期号:41 页码:8203-8211
关键词	COPOLYMER MICELLES ANTICANCER DRUGS CANCER-THERAPY PRO-DRUG DELIVERY NANOPARTICLES DOXORUBICIN ENCAPSULATION CISPLATIN POLYMERS
通讯作者	zhou,df
英文摘要	reduction-responsive nano-carriers have been confirmed to be promising for intracellular drug delivery. to develop multifunctional polymer-based drug delivery system, a novel dextran-pt(iv) conjugate was synthesized by conjugating pt(iv) to the side chains of the hydrophilic dextran and used for doxorubicin (dox) delivery. pt(iv) conjugation could change the hydrophilicity of dextran, leading to the self-assembly of dextran-pt(iv) conjugates with different morphologies. pt(iv) segments served as the key components in assembly formation and as the antitumor prodrug. under a reductive environment, pt(iv) was found to be reduced to its active pt(ii) form and cleaved from dextran, shifting the hydrophilic-hydrophobic balance of the dextran-pt(iv) conjugate. the collapse of the assembly structure due to the partial or complete recovery of the hydrophilicity of dextran led to triggered release of dox. the dox-loaded dextran-pt(iv) conjugate obtained by combining the released hydrophobic dox and recovered hydrophilic pt(ii), was found to be very effective as an antitumor agent as demonstrated in in vitro cytotoxicity evaluations. this dox-loaded dextran-pt(iv) conjugate system provided a new strategy to trigger the release of hydrophobic and hydrophilic drugs at the same time via single reduction-responsive control to provide an enhanced anti-tumor effect.
收录类别	SCI
语种	英语
WOS记录号	WOS:000363152900018
公开日期	2016-05-31
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/65086]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	He,Shasha,Cong,Yuwei,Zhou,Dongfang,et al. A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release[J]. journal of materials chemistry b,2015,3(41):8203-8211.
APA	He,Shasha.,Cong,Yuwei.,Zhou,Dongfang.,Li,Jizhen.,Xie,Zhigang.,...&Huang,Yubin.(2015).A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release.journal of materials chemistry b,3(41),8203-8211.
MLA	He,Shasha,et al."A dextran-platinum(IV) conjugate as a reduction-responsive carrier for triggered drug release".journal of materials chemistry b 3.41(2015):8203-8211.