Preparation of Hybrid Monolithic Columns via "One-Pot" Photoinitiated Thiol-Acrylate Polymerization for Retention-Independent Performance in Capillary Liquid Chromatography

	Preparation of Hybrid Monolithic Columns via "One-Pot" Photoinitiated Thiol-Acrylate Polymerization for Retention-Independent Performance in Capillary Liquid Chromatography
	Zhang, Haiyang 1,2; Ou, Junjie 1; Liu, Zhongshan 1,3; Wang, Hongwei 1,3; Wei, Yinmao 2; Zou, Hanfa 1
刊名	analytical chemistry
	2015-09-01
卷号	87 期号:17 页码:8789-8797
英文摘要	a novel "one-pot" approach was developed for ultrarapid preparation of various hybrid monolithic columns in uv-transparent fused-silica capillaries via photoinitiated thiol acrylate polymerization of an acrylopropyl polyhedral oligomertic silsesquioxane (acryl-poss) and a monothiol monomer (1-octadecanethiol or sodium 3-mercapto-l-propanesulfonate) within 5 min, in which the acrylate not only homopolymerizes, but also couples with the thiol. this unique combination of two types of free-radical reaction mechanisms offers a simple way to fabricate various acrylate-based hybrid monoliths. the physical characterization, including scanning electron microscopy (sem), fourier transform infrared (ft-ir) spectroscopy, and thermal gravimetric analysis was performed. the results indicated that the monothiol monomers were successfully incorporated into acryl-poss-based hybrid monoliths. the column efficiencies for alkylbenzenes on the c18-functionalized hybrid monolithic column reached to 60;000-73 500 plates/m at the velocity of 0.33 mm/s in capillary liquid chromatography, which was far higher than that of previously reported poss-based columns prepared via thermal-initiated free-radical polymerization without adding any thiol monomers. by plotting the plate height (h) of the alkylbenzenes versus the linear velocity (u) of the mobile phase, the results revealed a retention-independent efficient performance of small molecules in the isocratic elution. these results indicated that more homogeneous hybrid monoliths formed via photoinitiated thiol acrylate polymerization; particularly, the use of the multifunctional cross-linker possibly prevented the generation of gel-like micropores, reducing mass transfer resistance (c-term). another sulfonate-containing hybrid monolithic column also exhibited hydrophobicity and ion-exchange mechanism, and the dynamic binding capacity was calculated as 71.1 ng/cm (75 mu m i.d.).
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, analytical
研究领域[WOS]	chemistry
关键词[WOS]	polyhedral oligomeric silsesquioxane ; ring-opening polymerization ; ene click chemistry ; small molecules ; stationary phases ; reversed-phase ; separation ; electrochromatography ; functionalization ; morphology
收录类别	SCI
语种	英语
WOS记录号	WOS:000360773100029
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146528]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.NW Univ Xian, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Haiyang,Ou, Junjie,Liu, Zhongshan,et al. Preparation of Hybrid Monolithic Columns via "One-Pot" Photoinitiated Thiol-Acrylate Polymerization for Retention-Independent Performance in Capillary Liquid Chromatography[J]. analytical chemistry,2015,87(17):8789-8797.
APA	Zhang, Haiyang,Ou, Junjie,Liu, Zhongshan,Wang, Hongwei,Wei, Yinmao,&Zou, Hanfa.(2015).Preparation of Hybrid Monolithic Columns via "One-Pot" Photoinitiated Thiol-Acrylate Polymerization for Retention-Independent Performance in Capillary Liquid Chromatography.analytical chemistry,87(17),8789-8797.
MLA	Zhang, Haiyang,et al."Preparation of Hybrid Monolithic Columns via "One-Pot" Photoinitiated Thiol-Acrylate Polymerization for Retention-Independent Performance in Capillary Liquid Chromatography".analytical chemistry 87.17(2015):8789-8797.