Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells

	Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells
	Xia, Zhengxiang 1,2; Zhang, Hong 1,2; Xu, Danqing 1,2; Lao, Yuanzhi 1,2; Fu, Wenwei 1,2; Tan, Hongsheng 1,2; Cao, Peng 3; Yang, Ling 4; Xu, Hongxi 1,2
刊名	molecules
	2015-06-01
卷号	20 期号:6 页码:11387-11399
关键词	Garcinia cowa xanthone cytotoxicity apoptosis cell cycle arrest autophagy
英文摘要	two new xanthones, cowaxanthones g (1) and h (2), and 23 known analogues were isolated from an acetone extract of the leaves of garcinia cowa. the isolated compounds were evaluated for cytotoxicity against three cancer cell lines and immortalized hl7702 normal liver cells, whereby compounds 1, 5, 8, and 15-17 exhibited significant cytotoxicity. cell cycle analysis using flow cytometry showed that 5 induced cell cycle arrest at the s phase in a dose-dependent manner, 1 and 16 at the g2/m phase, and 17 at the g1 phase, while 16 and 17 induced apoptosis. moreover, autophagy analysis by gfp-lc3 puncta formation and western blotting suggested that 17 induced autophagy. taken together, our results suggest that these xanthones possess anticancer activities targeting cell cycle, apoptosis, and autophagy signaling pathways.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, organic
研究领域[WOS]	chemistry
关键词[WOS]	polyprenylated benzoylphloroglucinol derivatives ; prenylated xanthones ; mangostana ; twigs ; benzophenone ; constituents ; metabolism ; bark
收录类别	SCI
语种	英语
WOS记录号	WOS:000357992700115
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146402]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China 2.Shanghai Coll TCM New Drug Discovery, Engn Res Ctr, Shanghai 201203, Peoples R China 3.Jiangsu Prov Acad Tradit Chinese Med, Nanjing 210028, Jiangsu, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Xia, Zhengxiang,Zhang, Hong,Xu, Danqing,et al. Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells[J]. molecules,2015,20(6):11387-11399.
APA	Xia, Zhengxiang.,Zhang, Hong.,Xu, Danqing.,Lao, Yuanzhi.,Fu, Wenwei.,...&Xu, Hongxi.(2015).Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells.molecules,20(6),11387-11399.
MLA	Xia, Zhengxiang,et al."Xanthones from the Leaves of Garcinia cowa Induce Cell Cycle Arrest, Apoptosis, and Autophagy in Cancer Cells".molecules 20.6(2015):11387-11399.