Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry

	Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry
	Liu, Xinyu 1; Zheng, Peng 2,3; Zhao, Xinjie 1; Zhang, Yuqing 2,3; Hu, Chunxiu 1; Li, Jia 1; Zhao, Jieyu 1; Zhou, Jingjing 2,3; Xie, Peng 2,3; Xu, Guowang 1
刊名	journal of proteome research
	2015-05-01
卷号	14 期号:5 页码:2322-2330
英文摘要	major depressive disorder (mdd) is a debilitating mental disease with a pronounced impact on the quality of life of many people; however, it is still difficult to diagnose mdd accurately. in this study, a nontargeted metabolomics approach based on ultra-high-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (uplc-q-tof/ms) was used to find the differential metabolites in plasma samples from patients with mdd and healthy controls. furthermore, a validation analysis focusing on the differential metabolites was performed in another batch of samples using a targeted approach based on the dynamic multiple reactions monitoring method. levels of acyl carnitines, ether lipids, and tryptophan pronouncedly decreased, whereas lpcs, lpes, and pes markedly increased in mdd subjects as compared with the healthy controls. disturbed pathways, mainly located in acyl carnitine metabolism, lipid metabolism, and tryptophan metabolism, were clearly brought to light in mdd subjects. the binary logistic regression result showed that carnitine c10:1, pe-o 36:5, lpe 18:1 sn-2, and tryptophan can be used as a combinational biomarker to distinguish not only moderate but also severe mdd from healthy control with good sensitivity and specificity. our findings, on one hand, provide critical insight into the pathological mechanism of mdd and, on the other hand, supply a combinational biomarker to aid the diagnosis of mdd in clinical usage.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	biochemical research methods
研究领域[WOS]	biochemistry & molecular biology
关键词[WOS]	oxidative stress ; rat model ; prefrontal cortex ; surrogate marker ; mood disorders ; mild stress ; acetylcarnitine ; metabolomics ; metabolism ; carnitine
收录类别	SCI
语种	英语
WOS记录号	WOS:000354004700030
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146252]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China 3.Chongqing Med Univ, Inst Neurosci, Chongqing 400016, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xinyu,Zheng, Peng,Zhao, Xinjie,et al. Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry[J]. journal of proteome research,2015,14(5):2322-2330.
APA	Liu, Xinyu.,Zheng, Peng.,Zhao, Xinjie.,Zhang, Yuqing.,Hu, Chunxiu.,...&Xu, Guowang.(2015).Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry.journal of proteome research,14(5),2322-2330.
MLA	Liu, Xinyu,et al."Discovery and Validation of Plasma Biomarkers for Major Depressive Disorder Classification Based on Liquid Chromatography-Mass Spectrometry".journal of proteome research 14.5(2015):2322-2330.