A protease inhibition strategy based on acceleration of autolysis

	A protease inhibition strategy based on acceleration of autolysis
	Lv, Yan; Zhang, Jianbin; Wu, Hao; Zhao, Shan; Song, Yizhe; Wang, Shujun; Wang, Bing; Lv, Guojun; Ma, Xiaojun
刊名	chemical communications
	2015
卷号	51 期号:27 页码:5959-5962
英文摘要	we report on an iconoclastic strategy for inhibiting proteases via autolysis acceleration. we show that proteases can be concentrated and induced to rapidly self-digest by a biocompatible polymer serving as an efficient catalyst. this new generation of protease inhibitors may find applications in the treatment of various protease-dependent diseases.
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	trypsin-inhibitor ; delivery
收录类别	SCI
语种	英语
WOS记录号	WOS:000351660500037
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146123]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	Chinese Acad Sci, Dalian Inst Chem Phys, Lab Biomed Mat Engn, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Lv, Yan,Zhang, Jianbin,Wu, Hao,et al. A protease inhibition strategy based on acceleration of autolysis[J]. chemical communications,2015,51(27):5959-5962.
APA	Lv, Yan.,Zhang, Jianbin.,Wu, Hao.,Zhao, Shan.,Song, Yizhe.,...&Ma, Xiaojun.(2015).A protease inhibition strategy based on acceleration of autolysis.chemical communications,51(27),5959-5962.
MLA	Lv, Yan,et al."A protease inhibition strategy based on acceleration of autolysis".chemical communications 51.27(2015):5959-5962.