Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway

	Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway
	Wu, Shan 1; Xu, Hui 2; Peng, Jinyong 1; Wang, Changyuan 1; Jin, Yue 1; Liu, Kexin 1; Sun, Huijun 1; Qin, Jianhua 2
刊名	biochimie
	2015-03-01
卷号	110c 页码:62-72
关键词	Dioscin TNF-alpha NF-kappa B pathways EL HUVECs Monocytes
英文摘要	the modulation of adhesion molecule expression and the reduction of aberrant leukocyte adhesion to the endothelium are attractive approaches for treating inflammation-related vascular complications, including atherosclerosis. dioscin has a variety of biological activities including anti-inflammatory activity. however, the molecular mechanisms behind dioscin's anti-inflammatory effects are not fully understood. in this study, we investigated the molecular mechanism involved in the effects of dioscin on inflammatory mediators in tumor necrosis factor-alpha (tnf-alpha)-stimulated human umbilical vein endothelial cells (huvecs). in vitro, dioscin decreased monocyte adhesion to tnf-alpha-treated huvecs by reducing vascular cell adhesion molecule-1 (vcam-1) and intercellular adhesion molecule 1 (icam-1) expression and inhibiting endothelial lipase (el) expression in tnf-a-treated huvecs and macrophages by blocking the nuclear factor-kappa b (nf-kappa b) pathway. thus, dioscin might inhibit inflammation by interrupting the nf-kappa b signaling pathway and could potentially contribute to treatments for inflammatory diseases and atherosclerosis. (c) 2015 elsevier b.v. and societe francaise de biochimie et biologie moleculaire (sfbbm). all rights reserved.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	biochemistry & molecular biology
研究领域[WOS]	biochemistry & molecular biology
关键词[WOS]	endothelial-cell-adhesion ; atherosclerotic lesion ; linking inflammation ; lipase ; activation ; atherogenesis ; mechanisms ; molecules ; cytokines ; diseases
收录类别	SCI
语种	英语
WOS记录号	WOS:000350920400007
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/146113]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Med Univ, Coll Pharm, Dept Clin Pharmacol, Dalian 116044, Liaoning Provin, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dept Biotechnol, Dalian 116023, Liaoning Provin, Peoples R China
推荐引用方式 GB/T 7714	Wu, Shan,Xu, Hui,Peng, Jinyong,et al. Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway[J]. biochimie,2015,110c:62-72.
APA	Wu, Shan.,Xu, Hui.,Peng, Jinyong.,Wang, Changyuan.,Jin, Yue.,...&Qin, Jianhua.(2015).Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway.biochimie,110c,62-72.
MLA	Wu, Shan,et al."Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-alpha-induced VCAM-1, ICAM-1 and EL expression via the NF-kappa B pathway".biochimie 110c(2015):62-72.