Design, simulation and evaluation of improved air amplifier incorporating an ion funnel for nano-ESI MS

	Design, simulation and evaluation of improved air amplifier incorporating an ion funnel for nano-ESI MS
	Jurcicek, Petr 1; Liu, Lingpeng 1; Zou, Helin 1; An, Zhiqi 1; Xiao, Hongbin 2
刊名	european journal of mass spectrometry
	2014
卷号	20 期号:2 页码:143-154
关键词	ESI nanoelectrospray air amplifier ion focusing ion funnel computational fluid dynamics ion trajectory
英文摘要	an improved air amplifier design that takes advantage of the combined effects of aerodynamic and electrodynamic focusing was developed to couple a nanoelectrospray ionisation (nano-esi) source and the heated mass spectrometer inlet to improve the sensitivity of a mass spectrometer. the new design comprises an electrodynamic ion funnel integrated into the main air pathway of the air amplifier to more effectively focus and transmit gas-phase ions from the nano-esi source into the heated mass spectrometer inlet. numerical computational fluid dynamics simulations were carried out using a commercial software package, ansys fluent, to provide more detailed information about the device's performance. the gas flow field as well as the electric field patterns and the lagrangian ion motion were conveniently simulated using this single package and custom-written, user-defined functions. experimental results show a nearly five-fold improvement in reserpine ion intensity with the air amplifier operated at a nitrogen gauge pressure of 40 kpa and no direct current (dc) or radiofrequency (rf) potentials applied to the ion funnel when the distance between the electrospray emitter and sampling inlet tube was 24 mm, as compared to direct sample infusion from the same distance without the air amplifier. more importantly, a nearly three-fold additional gain in ion intensity was measured when both dc and rf potentials were co-applied, resulting in more than a 13-fold overall ion intensity gain which could be attributed to the combined air amplifier aerodynamic and ion funnel electrodynamic focusing effect.
WOS标题词	science & technology ; physical sciences ; technology
类目[WOS]	physics, atomic, molecular & chemical ; spectroscopy
研究领域[WOS]	physics ; spectroscopy
关键词[WOS]	ionization-mass-spectrometry ; electrospray-ionization ; atmospheric-pressure ; venturi device ; interface ; transmission ; flow ; efficiency
收录类别	SCI
语种	英语
WOS记录号	WOS:000334729200003
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/145743]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Dalian Univ Technol, Key Lab Micronano Syst & Technol Liaoning Prov, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Jurcicek, Petr,Liu, Lingpeng,Zou, Helin,et al. Design, simulation and evaluation of improved air amplifier incorporating an ion funnel for nano-ESI MS[J]. european journal of mass spectrometry,2014,20(2):143-154.
APA	Jurcicek, Petr,Liu, Lingpeng,Zou, Helin,An, Zhiqi,&Xiao, Hongbin.(2014).Design, simulation and evaluation of improved air amplifier incorporating an ion funnel for nano-ESI MS.european journal of mass spectrometry,20(2),143-154.
MLA	Jurcicek, Petr,et al."Design, simulation and evaluation of improved air amplifier incorporating an ion funnel for nano-ESI MS".european journal of mass spectrometry 20.2(2014):143-154.