Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics

	Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics
	Ye, Guozhu 1; Liu, Ying 2; Yin, Peiyuan 1; Zeng, Zhongda 1; Huang, Qiang 1; Kong, Hongwei 1; Lu, Xin 1; Zhong, Laiping 2; Zhang, Zhiyuan 2; Xu, Guowang 1
刊名	journal of proteome research
	2014-04-01
卷号	13 期号:4 页码:1994-2004
关键词	pseudotargeted metabolomics oral squamous cell carcinoma potential biomarkers induction chemotherapy metabolomics personalized medicine
英文摘要	the effect of induction chemotherapy on oral cancer is controversial owing to inconsistent results. however, the efficacy of induction chemotherapy is closely related to locoregional recurrence, distant metastasis, and overall survival after the treatment. a pseudotargeted metabolomics revealed that metabolites involved in glycolysis and amino acid metabolism were inversely regulated in patients with different before operation chemotherapy responses, and most fatty acids, steroids, and antioxidant substances were up-regulated in all patients after the treatment. among the metabolites, lactic acid, glucose, glutamic acid, aspartic acid, leucine, and glycerol were remarkably associated with induction chemotherapy efficacy. subsequently, lactic acid, glutamic acid, and aspartic acid were defined as potential biomarkers of the suitability and efficacy of induction chemotherapy. our results show that 100.0 and 84.37% of patients with different chemotherapy efficacy were correctly identified in the training and test sets, respectively. moreover, patient suitability for treatment was correctly predicted for 100.0, 81.25, and 100.0% of patients in the training, test, and external validation sets, respectively. in conclusion, metabolites related to glycolysis, redox homeostasis, and anabolic progress were indicative of induction chemotherapy efficacy both pre- and post-chemotherapy and beneficial for outcome evaluation and prediction. these results illustrate the potentials of metabolomics in personalized induction chemotherapy.
WOS标题词	science & technology ; life sciences & biomedicine
类目[WOS]	biochemical research methods
研究领域[WOS]	biochemistry & molecular biology
关键词[WOS]	mass-spectrometry ; cross-validation ; breast-cancer ; stem-cells ; serum ; performance ; signatures ; biomarker ; selection ; trial
收录类别	SCI
语种	英语
WOS记录号	WOS:000334016400020
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/145599]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 2.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Sch Med, Shanghai 200011, Peoples R China
推荐引用方式 GB/T 7714	Ye, Guozhu,Liu, Ying,Yin, Peiyuan,et al. Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics[J]. journal of proteome research,2014,13(4):1994-2004.
APA	Ye, Guozhu.,Liu, Ying.,Yin, Peiyuan.,Zeng, Zhongda.,Huang, Qiang.,...&Xu, Guowang.(2014).Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics.journal of proteome research,13(4),1994-2004.
MLA	Ye, Guozhu,et al."Study of Induction Chemotherapy Efficacy in Oral Squamous Cell Carcinoma Using Pseudotargeted Metabolomics".journal of proteome research 13.4(2014):1994-2004.