Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation

	Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation
	Wang, Changsong 1; Dong, Ran 1; Wang, Xiaoyang 1; Lian, Ailing 1; Chi, Chunjie 1; Ke, Chaofu 2; Guo, Lei 1; Liu, Shanshan 1; Zhao, Wei 1; Xu, Guowang 3
刊名	scientific reports
	2014-12-08
卷号	4 期号:1 页码:07312
通讯作者	李恩有
英文摘要	in this study, single-lung ventilation was used to detect differences in the volatile organic compound (vocs) profiles between lung tissues in healthy and affected lungs. in addition, changes that occurred after lung cancer resection in both the vocs profiles of exhaled breath from ipsilateral and contralateral lungs and the vocs profiles of exhaled breath and blood sample headspaces were also determined. eighteen patients with non-small cell carcinoma were enrolled. alveolar breath samples were taken separately from healthy and diseased lungs before and after the tumor resection. solid phase microextraction-gas chromatography/mass spectrometry was used to assess the exhaled vocs of the study participants. the vocs exhibited significant differences between the contralateral and ipsilateral lungs before surgery, the contralateral and ipsilateral lungs after surgery, the ipsilateral lungs before and after surgery, and the blood samples from before and after surgery; 12, 19, 12 and 5 characteristic metabolites played decisive roles in sample classification, respectively. 2,2-dimethyldecane, tetradecane, 2,2,4,6,6-pentamethylheptane, 2,3,4-trimethyldecane, nonane, 3,4,5,6-tetramethyloctane, and hexadecane may be generated from lipid peroxidation during surgery. caprolactam and propanoic acid may be more promising exhaled breath biomarkers for lung cancer.
学科主题	物理化学
WOS标题词	science & technology
类目[WOS]	multidisciplinary sciences
研究领域[WOS]	science & technology - other topics
关键词[WOS]	gas chromatography/mass spectrometry ; solid-phase microextraction ; cells in-vitro ; breath analysis ; release ; markers
收录类别	SCI
语种	英语
WOS记录号	WOS:000346272400001
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/144195]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Harbin Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Harbin, Peoples R China 2.Harbin Med Univ, Sch Publ Hlth, Dept Biostat, Harbin, Peoples R China 3.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Wang, Changsong,Dong, Ran,Wang, Xiaoyang,et al. Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation[J]. scientific reports,2014,4(1):07312.
APA	Wang, Changsong.,Dong, Ran.,Wang, Xiaoyang.,Lian, Ailing.,Chi, Chunjie.,...&Li, Enyou.(2014).Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation.scientific reports,4(1),07312.
MLA	Wang, Changsong,et al."Exhaled volatile organic compounds as lung cancer biomarkers during one-lung ventilation".scientific reports 4.1(2014):07312.