Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats
Liu, Peng1,2; Zhang, JianJun1; Li, Ming3; Sui, Nan1
刊名FRONTIERS IN BEHAVIORAL NEUROSCIENCE
2016-03-15
卷号10期号:50页码:1-10
关键词DNA methylation 5-aza-2 '-deoxycytidine morphine addiction conditioned place aversion insular amygdala
ISSN号1662-5153
英文摘要5-aza-2'-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases (DNMTs), has been implicated in aversive memory and the function of brain region involved in processing emotion. However, little is known about the role of 5-aza in the reconsolidation of opiate withdrawal memory. In the present study, using the morphine-naloxone induced conditioned place aversion (CPA) model in rats, we injected 5-aza into agranular insular (AI), granular insular (GI), basolateral amygdala (BLA) and central amygdala (CeA) immediately after the memory retrieval and tested the behavioral consequences at 24 h, 7 and 14 days after retrieval test. We found that 5-aza injection into AI disrupted the reconsolidation of morphine-associated withdrawal memory, but 5-aza injection into GI had no impact on the reconsolidation. Meanwhile, 5-aza injection into BLA but not CeA attenuated the withdrawal memory trace 14 days later. However, 5-aza administration to rats, in the absence of memory reactivation, had no effect on morphine-associated withdrawal memory. These findings suggest that 5-aza interferes with the reconsolidation of opiate withdrawal memory, and the roles of insular and amygdala in reconsolidation are distinctive.
WOS标题词Science & Technology ; Life Sciences & Biomedicine
类目[WOS]Behavioral Sciences ; Neurosciences
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]INDUCED PLACE PREFERENCE ; LONG-TERM-MEMORY ; SYNAPTIC PLASTICITY ; LATERAL AMYGDALA ; DNA METHYLATION ; FEAR MEMORY ; DRUG MEMORY ; CORTEX ; DISRUPTION ; RETRIEVAL
收录类别SCI
语种英语
WOS记录号WOS:000371975300001
内容类型期刊论文
源URL[http://ir.psych.ac.cn/handle/311026/19698]  
专题心理研究所_中国科学院心理健康重点实验室
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Univ Chinese Acad Sci, Beijing, Peoples R China
3.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA
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Liu, Peng,Zhang, JianJun,Li, Ming,et al. Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2016,10(50):1-10.
APA Liu, Peng,Zhang, JianJun,Li, Ming,&Sui, Nan.(2016).Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,10(50),1-10.
MLA Liu, Peng,et al."Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 10.50(2016):1-10.
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