Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats | |
Liu, Peng1,2; Zhang, JianJun1![]() ![]() | |
刊名 | FRONTIERS IN BEHAVIORAL NEUROSCIENCE
![]() |
2016-03-15 | |
卷号 | 10期号:50页码:1-10 |
关键词 | DNA methylation 5-aza-2 '-deoxycytidine morphine addiction conditioned place aversion insular amygdala |
ISSN号 | 1662-5153 |
英文摘要 | 5-aza-2'-deoxycytidine (5-aza), an inhibitor of DNA methyltransferases (DNMTs), has been implicated in aversive memory and the function of brain region involved in processing emotion. However, little is known about the role of 5-aza in the reconsolidation of opiate withdrawal memory. In the present study, using the morphine-naloxone induced conditioned place aversion (CPA) model in rats, we injected 5-aza into agranular insular (AI), granular insular (GI), basolateral amygdala (BLA) and central amygdala (CeA) immediately after the memory retrieval and tested the behavioral consequences at 24 h, 7 and 14 days after retrieval test. We found that 5-aza injection into AI disrupted the reconsolidation of morphine-associated withdrawal memory, but 5-aza injection into GI had no impact on the reconsolidation. Meanwhile, 5-aza injection into BLA but not CeA attenuated the withdrawal memory trace 14 days later. However, 5-aza administration to rats, in the absence of memory reactivation, had no effect on morphine-associated withdrawal memory. These findings suggest that 5-aza interferes with the reconsolidation of opiate withdrawal memory, and the roles of insular and amygdala in reconsolidation are distinctive. |
WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
类目[WOS] | Behavioral Sciences ; Neurosciences |
研究领域[WOS] | Behavioral Sciences ; Neurosciences & Neurology |
关键词[WOS] | INDUCED PLACE PREFERENCE ; LONG-TERM-MEMORY ; SYNAPTIC PLASTICITY ; LATERAL AMYGDALA ; DNA METHYLATION ; FEAR MEMORY ; DRUG MEMORY ; CORTEX ; DISRUPTION ; RETRIEVAL |
收录类别 | SCI |
语种 | 英语 |
WOS记录号 | WOS:000371975300001 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/19698] ![]() |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Univ Nebraska, Dept Psychol, Lincoln, NE 68588 USA |
推荐引用方式 GB/T 7714 | Liu, Peng,Zhang, JianJun,Li, Ming,et al. Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats[J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE,2016,10(50):1-10. |
APA | Liu, Peng,Zhang, JianJun,Li, Ming,&Sui, Nan.(2016).Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats.FRONTIERS IN BEHAVIORAL NEUROSCIENCE,10(50),1-10. |
MLA | Liu, Peng,et al."Distinctive Roles of 5-aza-2 '-deoxycytidine in Anterior Agranular Insular and Basolateral Amygdala in Reconsolidation of Aversive Memory Associated with Morphine in Rats".FRONTIERS IN BEHAVIORAL NEUROSCIENCE 10.50(2016):1-10. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论