Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy

	Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy
	Xiong,Hejian; Zhou,Dongfang; Qi,Yanxin; Zhang,Zhiyun; Xie,Zhigang; Chen,Xuesi; Jing,Xiabin; Meng,Fanbo; Huang,Yubin
刊名	biomacromolecules
	2015
卷号	16 期号:12 页码:3980-3988
关键词	NEUTRON-CAPTURE THERAPY DRUG-DELIVERY DIHYDROGEN BONDS CLICK CHEMISTRY BORON MICELLES METALLACARBORANES LIPOSOMES CARRIERS CELLS
通讯作者	meng,fb
英文摘要	carborane-conjugated amphiphilic copolymer nanoparticles were designed to deliver anticancer drugs for the combination of chemotherapy and boron neutron capture therapy (bnct). poly(ethylene glycol)-b-poly(l-lactide-co-2-methyl-2 (2-dicarba-closo-dodecarborane) propyloxycarbonyl-propyne carbonate) (plmb) was synthesized via the versatile reaction between decaborane and side alkynyl groups, and self-assembled with doxorubicin (dox) to form drug-loaded nanoparticles. these dox@plmb nanoparticles could not only suppress the leakage of the boron compounds into the bloodstream due to the covalent bonds between carborane and polymer main chains, but also protect dox from initial burst release at physiological conditions because of the dihydrogen bonds between dox and carborane. it was demonstrated that dox@plmb nanoparticles could selectively deliver boron atoms and dox to the tumor site simultaneously in vivo. under the combination of chemotherapy and bnct, the highest tumor suppression efficiency without reduction of body weight was achieved. this polymeric nanoparticles delivery system could be very useful in future chemoradiotherapy to obtain improved therapeutic effect with reduced systemic toxicity.
收录类别	SCI
语种	英语
WOS记录号	WOS:000366616700028
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64821]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xiong,Hejian,Zhou,Dongfang,Qi,Yanxin,et al. Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy[J]. biomacromolecules,2015,16(12):3980-3988.
APA	Xiong,Hejian.,Zhou,Dongfang.,Qi,Yanxin.,Zhang,Zhiyun.,Xie,Zhigang.,...&Huang,Yubin.(2015).Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy.biomacromolecules,16(12),3980-3988.
MLA	Xiong,Hejian,et al."Doxorubicin-Loaded Carborane-Conjugated Polymeric Nanoparticles as Delivery System for Combination Cancer Therapy".biomacromolecules 16.12(2015):3980-3988.