Synthesis and Functions of Well-defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancer(a)

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	Synthesis and Functions of Well-defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancer(a)
	Yu, Qingsong 1; Zhang, Jiajing 3; Zhang, Guan 2; Gan, Zhihua 1
刊名	MACROMOLECULAR BIOSCIENCE
	2015-04-01
卷号	15 期号:4 页码:509-520
关键词	cancer chemotherapy drug conjugates
英文摘要	Novel poly(ethylene glycol) and poly(N-(2-hydroxypropyl) methacrylamide) block copolymer (PEG-b-PHPMA) with well-defined composition was synthesized by RAFT polymerization. Folate and doxorubicin (DOX) were quantitatively introduced into the copolymer. The influences of folate content and pH value on folate receptor (FR) mediated cell endocytosis and pH-responsive DOX release were studied. It has been demonstrated that minimum folate content is needed for the enrichment of hydrophobic folate on the hydrophilic part of polymer conjugates. The cytotoxicity of targetable polymer drug conjugates was much higher than that of non-targetable ones and free DOX. It could be concluded that the folate plays a significant role in targeting and internalization of the conjugates against bladder cancer cells.
收录类别	SCI
语种	英语
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/28563]
专题	化学研究所_分子纳米结构与纳米技术实验室
作者单位	1.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing Lab Biomed Mat, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China 2.China Japan Friendship Hosp, Dept Urol, Beijing 100029, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Yu, Qingsong,Zhang, Jiajing,Zhang, Guan,et al. Synthesis and Functions of Well-defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancer(a)[J]. MACROMOLECULAR BIOSCIENCE,2015,15(4):509-520.
APA	Yu, Qingsong,Zhang, Jiajing,Zhang, Guan,&Gan, Zhihua.(2015).Synthesis and Functions of Well-defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancer(a).MACROMOLECULAR BIOSCIENCE,15(4),509-520.
MLA	Yu, Qingsong,et al."Synthesis and Functions of Well-defined Polymer-drug Conjugates as Efficient Nanocarriers for Intravesical Chemotherapy of Bladder Cancer(a)".MACROMOLECULAR BIOSCIENCE 15.4(2015):509-520.