Layer by layer assembly of albumin nanoparticles with selective recognition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

CORC > 化学研究所 > 中国科学院化学研究所 > 胶体、界面与化学热力学实验室

	Layer by layer assembly of albumin nanoparticles with selective recognition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
	Cui, Wei 1; Wang, Anhe 2; Zhao, Jie 1; Yang, Xiaoke 1; Cai, Peng 1; Li, Junbai 1,2
刊名	JOURNAL OF COLLOID AND INTERFACE SCIENCE
	2016-03-01
卷号	465 页码:11-17
关键词	Layer-by-layer Nanoparticles Albumin TRAIL Core-shell
英文摘要	Crosslinked albumin nanoparticles which loaded with doxorubicin (DOX) were fabricated with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and biocompatible polysaccharide, alginate (ALG), using layer-by-layer technique. Albumin nanoparticles exhibited narrow size distribution and fluorescent property. The assembled core/shell structure of the nanoparticles can be internalized more easily with the cancer cells, which attributes to TRAIL binding with death receptors. TRAIL still hold bioactive properties after assembled onto the particles. In addition, after loaded into the albumin core nanoparticles, DOX (as the chemotherapeutics) display a synergistic cytotoxic effect on cytotoxicity in combination with TRAIL in vitro. The core/shell nanostructured nanoparticles realized in this study would be used as a promising candidate for novel drug carriers. (C) 2015 Elsevier Inc. All rights reserved.
收录类别	SCI
语种	英语
公开日期	2016-05-09
内容类型	期刊论文
源URL	[http://ir.iccas.ac.cn/handle/121111/29779]
专题	化学研究所_胶体、界面与化学热力学实验室
作者单位	1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Inst Chem, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Cui, Wei,Wang, Anhe,Zhao, Jie,et al. Layer by layer assembly of albumin nanoparticles with selective recognition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)[J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE,2016,465:11-17.
APA	Cui, Wei,Wang, Anhe,Zhao, Jie,Yang, Xiaoke,Cai, Peng,&Li, Junbai.(2016).Layer by layer assembly of albumin nanoparticles with selective recognition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).JOURNAL OF COLLOID AND INTERFACE SCIENCE,465,11-17.
MLA	Cui, Wei,et al."Layer by layer assembly of albumin nanoparticles with selective recognition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)".JOURNAL OF COLLOID AND INTERFACE SCIENCE 465(2016):11-17.