Synthesis of a highly fluorescence nitrogen-doped carbon quantum dots bioimaging probe and its in vivo clearance and printing applications

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	Synthesis of a highly fluorescence nitrogen-doped carbon quantum dots bioimaging probe and its in vivo clearance and printing applications
	Parvin, Nargish 1,3; Mandal, Tapas K.2,3
刊名	RSC ADVANCES
	2016
卷号	6 期号:22 页码:18134-18140
关键词	COATED GOLD NANOPARTICLES SENSITIVE DETECTION FACILE SYNTHESIS RENAL CLEARANCE GRAPHENE OXIDE NANODOTS TOXICITY IONS SIZE BIODISTRIBUTION
ISSN号	2046-2069
通讯作者	Mandal, TK (reprint author), Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China.
英文摘要	Highly fluorescent, broad range pH and ionic-stable N-doped carbon quantum dots (N-CQDs) were successfully synthesized and their chemical structure and fluorescence mechanism were characterized. Mono-dispersed N-CQDs averaging 4.5 nm in diameter were achieved in a quantum yield (QY) of 74.16%. These N-CQDs showed great potential in biomedical and optical imaging applications both in vivo and in vitro. Biodistribution, retention, toxicity, and pharmacokinetics profiles are mandatory in their potential clinical applications. Herein, the biodistribution, clearance, and toxicity of our invariable N-CQDs species were systematically investigated over 7 days in mice. Most of the N-CQDs were cleared at 6 days post-injection without any accumulation in any vital organs or tissues. Moreover, the high fluorescence N-CQDs were demonstrated to be effective as printing inks for multicolour patterns. This study suggests that N-CQDs may be an attractive alternative to metal quantum dots for secure biomedical and other industrial applications.
学科主题	Chemistry, Multidisciplinary ; Chemistry
WOS标题词	Science & Technology ; Physical Sciences
类目[WOS]	Chemistry, Multidisciplinary
研究领域[WOS]	Chemistry
关键词[WOS]	COATED GOLD NANOPARTICLES ; SENSITIVE DETECTION ; FACILE SYNTHESIS ; RENAL CLEARANCE ; GRAPHENE OXIDE ; NANODOTS ; TOXICITY ; IONS ; SIZE ; BIODISTRIBUTION
收录类别	SCI
原文出处	ROYAL SOC CHEMISTRY
语种	英语
WOS记录号	WOS:000370717900040
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/20708]
专题	过程工程研究所_研究所（批量导入）
作者单位	1.Chinese Acad Sci, Inst Proc Engn, Key Lab Biochem Engn, 1 Bei Erjie, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China 3.Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttar Pradesh, India
推荐引用方式 GB/T 7714	Parvin, Nargish,Mandal, Tapas K.. Synthesis of a highly fluorescence nitrogen-doped carbon quantum dots bioimaging probe and its in vivo clearance and printing applications[J]. RSC ADVANCES,2016,6(22):18134-18140.
APA	Parvin, Nargish,&Mandal, Tapas K..(2016).Synthesis of a highly fluorescence nitrogen-doped carbon quantum dots bioimaging probe and its in vivo clearance and printing applications.RSC ADVANCES,6(22),18134-18140.
MLA	Parvin, Nargish,et al."Synthesis of a highly fluorescence nitrogen-doped carbon quantum dots bioimaging probe and its in vivo clearance and printing applications".RSC ADVANCES 6.22(2016):18134-18140.