Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid

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	Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid
	Liu, Qingfen; Li, Yingbo; Li, Wangliang; Liang, Xiangfeng; Zhang, Chao; Liu, Huizhou
刊名	ACS SUSTAINABLE CHEMISTRY & ENGINEERING
	2016-02-01
卷号	4 期号:2 页码:609-615
关键词	Penicillin G Ionic liquids Liquid-liquid extraction Partition coefficient Mechanism
ISSN号	2168-0485
英文摘要	Penicillin G is a widely used antibiotic, but the traditional volatile organic solvent extraction causes serious environmental problems. In this work, a hydrophobic ionic liquid ([Bmim]PF6) was developed as a new extraction agent for recovery of penicillin G from aqueous solutions. The extraction efficiency and the partition coefficient of penicillin G were used as the indexes to evaluate the IL extraction ability. Key factors affecting the effectiveness of recovery, such as the pH of the aqueous solution, the initial concentration of penicillin G, and the IL-to-aqueous solution volume ratio, were investigated to determine the optimal conditions. The results showed that the pH of the aqueous phase strongly influenced the success of the extraction. The optimal pH value, phase ratio, and penicillin concentration were 1.5-2.0, 1.5/1 to 2.0/ 1, and 3.00-5.00 X 10(4) units/mL, respectively, whereby the partition coefficient and extraction efficiency were more than 30 and 91%, respectively. The extraction mechanism was explored by analyzing the chemical bonds using spectrographic analysis. Preliminary results indicated that penicillin G can be effectively extracted from fermentation broth by [Bmim]PF6 with extraction efficiencies of >87%. In addition, a higher selectivity and a much lower extent of emulsification were achieved by [Bmim]PF6 compared to those of butyl acetate. It demonstrates that the IL-based extraction strategy developed in this work is promising and effective, and as a result, the development of an IL-based extraction process for the recovery of penicillin G is straightforwardly envisaged.
WOS标题词	Science & Technology ; Physical Sciences ; Technology
类目[WOS]	Chemistry, Multidisciplinary ; Engineering, Chemical
研究领域[WOS]	Chemistry ; Engineering
关键词[WOS]	AQUEOUS 2-PHASE SYSTEM ; BETA-LACTAM ANTIBIOTICS ; FERMENTATION BROTH ; EXTRACTION ; SEPARATION ; SOLVENTS
收录类别	SCI
语种	英语
WOS记录号	WOS:000369347800029
内容类型	期刊论文
源URL	[http://ir.ipe.ac.cn/handle/122111/20612]
专题	过程工程研究所_湿法冶金清洁生产技术国家工程实验室
作者单位	Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, 1 BeiErJie, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qingfen,Li, Yingbo,Li, Wangliang,et al. Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid[J]. ACS SUSTAINABLE CHEMISTRY & ENGINEERING,2016,4(2):609-615.
APA	Liu, Qingfen,Li, Yingbo,Li, Wangliang,Liang, Xiangfeng,Zhang, Chao,&Liu, Huizhou.(2016).Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid.ACS SUSTAINABLE CHEMISTRY & ENGINEERING,4(2),609-615.
MLA	Liu, Qingfen,et al."Efficient Recovery of Penicillin G by a Hydrophobic Ionic Liquid".ACS SUSTAINABLE CHEMISTRY & ENGINEERING 4.2(2016):609-615.