NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING

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	NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING
	Wu, H.1,2; Wang, X.2; Gao, Y.2; Lin, F.2; Song, T.1,2; Zou, Y.1,2; Xu, L.2; Lei, H.1,2
刊名	NEUROSCIENCE
	2016-05-13
卷号	322 页码:221-233
关键词	N-methyl-D-aspartate receptor schizophrenia magnetic resonance imaging rat brain
英文摘要	Background: Animal models of N-methyl-Daspartate receptor (NMDAR) antagonism have been widely used for schizophrenia research. Less is known whether these models are associated with macroscopic brain structural changes that resemble those in clinical schizophrenia. Methods: Magnetic resonance imaging (MRI) was used to measure brain structural changes in rats subjected to repeated administration of MK801 in a regimen (daily dose of 0.2 mg/kg for 14 consecutive days) known to be able to induce schizophrenia-like cognitive impairments. Results: Voxel-based morphometry (VBM) revealed significant gray matter (GM) atrophy in the hippocampus, ventral striatum (vStr) and cortex. Diffusion tensor imaging (DTI) demonstrated microstructural impairments in the corpus callosum (cc). Histopathological results corroborated the MRI findings. Limitations: Treatment-induced behavioral abnormalities were not measured such that correlation between the brain structural changes observed and schizophrenia-like behaviors could not be established. Conclusion: Chronic MK801 administration induces MRI-observable brain structural changes that are comparable to those observed in schizophrenia patients, supporting the notion that NMDAR hypofunction contributes to the pathology of schizophrenia. Imaging-derived brain structural changes in animal models of NMDAR antagonism may be useful measurements for studying the effects of treatments and interventions targeting schizophrenia. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Neurosciences
研究领域[WOS]	Neurosciences & Neurology
关键词[WOS]	DENDRITIC SPINE DENSITY ; 1ST-EPISODE SCHIZOPHRENIA ; CORPUS-CALLOSUM ; ANIMAL-MODEL ; GRAY-MATTER ; MOUSE MODEL ; ANTIPSYCHOTIC TREATMENT ; PREPULSE INHIBITION ; MRI ; ABNORMALITIES
收录类别	SCI
语种	英语
WOS记录号	WOS:000372349800020
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9229]
专题	武汉物理与数学研究所_磁共振基础研究部
作者单位	1.Huazhong Univ Sci & Technol, Hubei Bioinformat & Mol Imaging Key Lab, Britton Chance Ctr Biomed Photon, Coll Life Sci & Technol,Wuhan Natl Lab Optoelect, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan, Wuhan, Peoples R China
推荐引用方式 GB/T 7714	Wu, H.,Wang, X.,Gao, Y.,et al. NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING[J]. NEUROSCIENCE,2016,322:221-233.
APA	Wu, H..,Wang, X..,Gao, Y..,Lin, F..,Song, T..,...&Lei, H..(2016).NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING.NEUROSCIENCE,322,221-233.
MLA	Wu, H.,et al."NMDA RECEPTOR ANTAGONISM BY REPETITIVE MK801 ADMINISTRATION INDUCES SCHIZOPHRENIA-LIKE STRUCTURAL CHANGES IN THE RAT BRAIN AS REVEALED BY VOXEL-BASED MORPHOMETRY AND DIFFUSION TENSOR IMAGING".NEUROSCIENCE 322(2016):221-233.