Neural Correlates of Prospective Memory Impairments in Schizophrenia

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	Neural Correlates of Prospective Memory Impairments in Schizophrenia
	Chen, Xing-jie 1,2; Wang, Ya1 ; Wang, Yi1 ; Yang, Tian-xiao1 ; Zou, Lai-quan 1,2; Huang, Jia1 ; Li, Feng-hua 3; Chen, An-tao 3; Wang, Wei-hong 3; Zheng, Han-feng 4
刊名	NEUROPSYCHOLOGY
	2016-02-01
卷号	30 期号:2 页码:169-180
关键词	functional imaging hypofrontality prospective memory schizophrenia
ISSN号	0894-4105
英文摘要	Objective: Prospective memory (PM) refers to the ability to remember to carry out intended actions after a delay. PM impairments are common in schizophrenia patients and are thought to be related to their prefrontal cortex dysfunction; however, this has not yet been examined directly in the research literature. The current study aimed to examine abnormalities in brain activation during PM task performance in schizophrenia patients. Method: Twenty-two schizophrenia patients and 25 matched healthy controls were scanned in a 3-T MRI machine while performing a PM task. Results: The results showed that compared to the healthy controls, schizophrenia patients performed significantly worse on the PM task. Furthermore, they exhibited decreased brain activation in frontal cortex including the right superior frontal gyri (Brodmann area 10), and other related brain areas like the anterior cingulate gyrus, parietal and temporal cortex, including precuneus, and some subcortext, including parahippocampal gyrus and putamen. Conclusions: These findings confirm the involvement and importance of the prefrontal cortex in PM and show evidence of hypofrontality in schizophrenia patients while performing a PM task.
WOS标题词	Social Sciences ; Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Psychology, Clinical ; Neurosciences ; Psychology
研究领域[WOS]	Psychology ; Neurosciences & Neurology
关键词[WOS]	ROSTRAL PREFRONTAL CORTEX ; WORKING-MEMORY ; EXECUTIVE FUNCTION ; FUNCTIONAL CONNECTIVITY ; DELAYED INTENTIONS ; BRAIN VOLUME ; 1ST-EPISODE SCHIZOPHRENIA ; EPISODIC MEMORY ; GYRUS VOLUME ; FMRI
收录类别	SCI ; SSCI
语种	英语
WOS记录号	WOS:000370070600004
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/19575]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Southwest Univ, Georgetown, TX USA 4.Beibei 2 Peoples Hosp, Beibei Mental Hlth Ctr, Chongqing, Peoples R China 5.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China 6.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Program, Nathan, Qld 4111, Australia
推荐引用方式 GB/T 7714	Chen, Xing-jie,Wang, Ya,Wang, Yi,et al. Neural Correlates of Prospective Memory Impairments in Schizophrenia[J]. NEUROPSYCHOLOGY,2016,30(2):169-180.
APA	Chen, Xing-jie.,Wang, Ya.,Wang, Yi.,Yang, Tian-xiao.,Zou, Lai-quan.,...&Chan, Raymond C. K..(2016).Neural Correlates of Prospective Memory Impairments in Schizophrenia.NEUROPSYCHOLOGY,30(2),169-180.
MLA	Chen, Xing-jie,et al."Neural Correlates of Prospective Memory Impairments in Schizophrenia".NEUROPSYCHOLOGY 30.2(2016):169-180.