The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder

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	The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder
	Jin, J.1,2,3; Liu, L.1,2,3; Gao, Q.1,2,3; Chan, R. C. K.4; Li, H.1,2,3; Chen, Y.1,2,3; Wang, Y.1,2,3; Qian, Q.1,2,3
刊名	GENES BRAIN AND BEHAVIOR
	2016-02-01
卷号	15 期号:2 页码:271-279
关键词	ADHD COMT development executive function Val158Met
ISSN号	1601-1848
英文摘要	Children with attention-deficit/hyperactivity disorder (ADHD) usually display deficits in executive function (EF), which are primarily mediated by prefrontal cortex (PFC). The functional polymorphism of catechol-O-methyltransferase (COMT), Val158Met (rs4680), leads to observed polymorphic differences in the degradation of dopamine within PFC. This study aimed to explore the effect of rs4680 on EF using case-control design. In addition, considering the dynamic development of EF, we also attempted to investigate whether this genetic influence changes during development or not. A total of 597 ADHD children and 154 unaffected controls were recruited. The EF was evaluated using Rey-Osterrieth complex figure test (RCFT), trail making test (TMT) and Stroop color and word test for working memory, shifting and inhibition. Association between genotype and EF was analyzed using analysis of covariance (ancova). The results showed significant interaction effect of genotype and ADHD diagnosis on RCFT performance (P<0.001). However, the associated genotypes between ADHD and controls were divergent. In ADHD, the Met carriers performed better than the Val homozygotes on detail immediate [(10.38 +/- 6.90) vs. (9.33 +/- 6.92), P=0.007] and detail delay [(9.96 +/- 6.86) vs. (8.86 +/- 6.89), P=0.004], while Val homozygotes showed better performance compared with Met carrier controls [for detail immediate (14.55 +/- 6.18) vs. (11.10 +/- 6.45), P<0.001; for detail delay (14.31 +/- 5.96) vs. (11.31 +/- 6.96), P=0.001]. We did not find significant interaction between genetic variant and development. COMTVal158Met (rs4680) may have divergent effect on working memory in ADHD children compared with healthy controls.
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Behavioral Sciences ; Neurosciences
研究领域[WOS]	Behavioral Sciences ; Neurosciences & Neurology
关键词[WOS]	CATECHOL-O-METHYLTRANSFERASE ; DEFICIT HYPERACTIVITY DISORDER ; 22Q11.2 DELETION SYNDROME ; CARDIO-FACIAL SYNDROME ; COGNITIVE FUNCTION ; WORKING-MEMORY ; VAL(158)MET POLYMORPHISM ; PREFRONTAL CORTEX ; NUCLEUS-ACCUMBENS ; GENOTYPE
收录类别	SCI
语种	英语
WOS记录号	WOS:000369768400006
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/19566]
专题	心理研究所_中国科学院心理健康重点实验室
作者单位	1.Peking Univ, Hosp 6, Inst Mental Hlth, 51 Hua Yuan Bei Lu, Beijing 100191, Peoples R China 2.Peking Univ, Hosp 6, Natl Clin Res Ctr Mental Disorders, 51 Hua Yuan Bei Lu, Beijing 100191, Peoples R China 3.Peking Univ, Key Lab Mental Hlth, Minist Hlth, 51 Hua Yuan Bei Lu, Beijing 100191, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Jin, J.,Liu, L.,Gao, Q.,et al. The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder[J]. GENES BRAIN AND BEHAVIOR,2016,15(2):271-279.
APA	Jin, J..,Liu, L..,Gao, Q..,Chan, R. C. K..,Li, H..,...&Qian, Q..(2016).The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder.GENES BRAIN AND BEHAVIOR,15(2),271-279.
MLA	Jin, J.,et al."The divergent impact of COMT Val158Met on executive function in children with and without attention-deficit/hyperactivity disorder".GENES BRAIN AND BEHAVIOR 15.2(2016):271-279.