Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe

CORC > 苏州纳米技术与纳米仿生研究所 > 中国科学院苏州纳米技术与纳米仿生研究所 > 纳米生物医学与安全研究部 > 王强斌团队

	Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe
	Li, CY(李春炎); Cao, LM(曹利敏); Zhang, YJ(张叶俊); Yi, PW(易佩伟); Wang, M(王懋); Tan, B(谭波); Deng, ZW(邓宗武); Wu, DM(吴东岷); Wang, QB(王强斌)
刊名	SMALL
	2015
卷号	11 期号:35 页码:9
关键词	Ag2S QDs dual modality nanoprobes nanoprobes image-guided surgery magnetic resonance imaging near-infrared fluorescence
通讯作者	Wang, QB (王强斌)
英文摘要	In clinical practice, it is difficult to identify tumor margins during brain surgery due to its inherent infiltrative character. Herein, a unique dual-modality nanoprobe (Gd-DOTA-Ag2S QDs, referred as Gd-Ag2S nanoprobe) is reported, which integrates advantages of the deep tissue penetration of enhanced magnetic resonance (MR) imaging of Gd and the high signal-to-noise ratio and high spatiotemporal resolution of fluorescence imaging in the second near-infrared window (NIR-II) of Ag2S quantum dots (QDs). Due to the abundant tumor angiogenesis and the enhanced permeability and retention effect in the tumor, a brain tumor (U87MG) in a mouse model is clearly delineated in situ with the help of the Gd assisted T1 MR imaging and the intraoperative resection of the tumor is precisely accomplished under the guidance of NIR-II fluorescence imaging of Ag2S QDs after intravenous injection of Gd-Ag2S nanoprobe. Additionally, no histologic changes are observed in the main organs of the mouse after administration of Gd-Ag2S nanoprobe for 1 month, indicating the high biocompatibility of the nanoprobe. We expect that such a novel Detection and Operation strategy based on Gd-Ag2S nanoprobe is promising in future clinical applications.
收录类别	SCI
语种	英语
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.sinano.ac.cn/handle/332007/3309]
专题	苏州纳米技术与纳米仿生研究所_纳米生物医学与安全研究部_王强斌团队苏州纳米技术与纳米仿生研究所_纳米仿生研究部_邓宗武团队苏州纳米技术与纳米仿生研究所_纳米研究国际实验室_吴东岷团队
推荐引用方式 GB/T 7714	Li, CY,Cao, LM,Zhang, YJ,et al. Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe[J]. SMALL,2015,11(35):9.
APA	Li, CY.,Cao, LM.,Zhang, YJ.,Yi, PW.,Wang, M.,...&Wang, QB.(2015).Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe.SMALL,11(35),9.
MLA	Li, CY,et al."Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe".SMALL 11.35(2015):9.