Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats

	Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats
	Feng WY(丰伟悦); Wang M(王萌); Yuan H(袁慧); Shi JW(史俊稳); Wang B(汪冰); Zhu MT(朱墨桃); Ou YH(欧阳宏); Zhao YL(赵宇亮); Chai ZF(柴之芳); Feng, WY
刊名	JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
	2011
卷号	26 期号:1 页码:#REF!
通讯作者	Feng, WY (reprint author), Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China.
英文摘要	A comparative study of methylmercury (MeHg) metabolism and its conversion into inorganic mercury (I-Hg) in organic tissues (brain, liver and kidney) and the subcellular fractions (nucleus, mitochondrion, lysosome, microsome and cytosol) of maternal and infant rats after infant in utero and lactational exposure to methylmercury was achieved by extraction preconcentration with HPLC-ICP-MS determination. The quantification of Hg-containing proteins in brain cytosol was studied by HPLC hyphenated on-line isotope dilution ICP-MS and the proteins were analyzed by SDS-PAGE and MALDI-TOF-MS. The results demonstrated that the methods could be successfully used in the study of mercury species in sub-compartments of organ cells. The study showed that the distribution patterns of MeHg and I-Hg in the levels of organs, the subcellular fractions of organs and proteins are all significantly different between mothers and their offspring, indicating their significantly different metabolism, transportation and accumulation behavior of mercury species, which may be all involved in the toxic mechanism of mercury for adults and young children.
学科主题	Chemistry; Spectroscopy
类目[WOS]	Chemistry, Analytical ; Spectroscopy
收录类别	SCI
WOS记录号	WOS:000285390600015
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/226561]
专题	高能物理研究所_院士高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Feng WY,Wang M,Yuan H,et al. Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats[J]. JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,2011,26(1):#REF!.
APA	丰伟悦.,王萌.,袁慧.,史俊稳.,汪冰.,...&Chai, ZF.(2011).Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats.JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY,26(1),#REF!.
MLA	丰伟悦,et al."Mercury speciation and mercury-binding protein study by HPLC-ICP-MS on the estimation of mercury toxicity between maternal and infant rats".JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY 26.1(2011):#REF!.