Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference

CORC > 高能物理研究所 > 中国科学院高能物理研究所 > 核技术应用研究中心

	Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference
	Tao, HJ; Wong, GHY; Zhang, HR; Zhou, Y; Xue, ZM; Shan, BC; Chen, EYH; Liu, ZN; Dan BC(单保慈)
刊名	PSYCHIATRY RESEARCH-NEUROIMAGING
	2015
卷号	233 期号:1 页码:57-63
关键词	Grey matter morphology Voxel-based morphometry Caudate Delusions
英文摘要	Delusions of reference (DOR) are theoretically linked with aberrant salience and associative learning. Previous studies have shown that the caudate nucleus plays a critical role in the cognitive circuits of coding prediction errors and associative learning. The current study aimed at testing the hypothesis that abnormalities in the caudate nucleus may be involved in the neuroanatomical substrate of DOR. Structural magnetic resonance imaging of the brain was performed in 44 first-episode psychosis patients (with diagnoses of schizophrenia or schizophreniform disorder) and 25 healthy controls. Patients were divided into three groups according to symptoms: patients with DOR as prominent positive symptom; patients with prominent positive symptoms other than DOR; and patients with minimal positive symptoms. All groups were age-, gender-, and education-matched, and patient groups were matched for diagnosis, duration of illness, and antipsychotic treatment. Voxel-based morphometric analysis was performed to identify group differences in grey matter density. Relationships were explored between grey matter density and DOR. Patients with DOR were found to have reduced grey matter density in the caudate compared with patients without DOR and healthy controls. Grey matter density values of the left and right caudate head were negatively correlated with DOR severity. Decreased grey matter density in the caudate nucleus may underlie DOR in early psychosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved
学科主题	Neurosciences & Neurology; Psychiatry
类目[WOS]	Clinical Neurology ; Neuroimaging ; Psychiatry
收录类别	SCI
WOS记录号	WOS:000355671600008
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228454]
专题	高能物理研究所_核技术应用研究中心
推荐引用方式 GB/T 7714	Tao, HJ,Wong, GHY,Zhang, HR,et al. Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference[J]. PSYCHIATRY RESEARCH-NEUROIMAGING,2015,233(1):57-63.
APA	Tao, HJ.,Wong, GHY.,Zhang, HR.,Zhou, Y.,Xue, ZM.,...&单保慈.(2015).Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference.PSYCHIATRY RESEARCH-NEUROIMAGING,233(1),57-63.
MLA	Tao, HJ,et al."Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference".PSYCHIATRY RESEARCH-NEUROIMAGING 233.1(2015):57-63.