Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study

	Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study
	Jiang, XF; Zhang, T; Sy, C; Nie, BB; Hu, XY; Ding, YC;聂彬彬
刊名	NEUROLOGICAL RESEARCH
	2014
卷号	36 期号:SI5 页码:475-482
关键词	Micro-PET Glucose metabolism Functional recovery Rehabilitation
英文摘要	Recent studies have suggested that rehabilitation therapy can accelerate functional recovery after a stroke. Although often overlooked, the cortical hemisphere contralateral to an infarction plays an important role. This study investigates alterations in metabolism of both the damaged ('ipsilateral') as well as the undamaged ('contralateral') hemisphere using F-18-fluorodeoxyglucose (FDG)-micro-positron emission tomography (PET) in a rat permanent stroke model (with or without post- injury exercise) in order to elucidate the relative importance of either hemisphere to the recovery process following stroke. Methods: Thirty-six adult, male Sprague- Dawley rats were divided into four groups before subsequent surgery: sham controls with or without exercise, and ischemic ('stroke') groups with or without exercise. Fluorodeoxyglucose micro- PET imaging was performed at 7, 14, and 21 days after the designated procedure according to group assignment. The imaging data was analyzed by ANOVA using SPMratIHEP software. Results: Both exercise and ischemia have measurable effects on the motor cortex as well as on the striatum, the effects of which notably include the contralateral hemisphere. To that end, regions of the contralateral motor cortex and striatum have been found to be in a hypermetabolic state following exercise. We further observed that exercise reversed the hypometabolism caused by ischemia back to control levels from day 7 through day 21 on the ipsilateral side. Its effect on the contralateral hemisphere, notably, bolsters an already vigorous response observed after ischemic insult. Thus, the beneficial effect of exercise, as inferred by an increase in metabolic activity, is evident in both hemispheres. Discussion: These findings suggest that the contralateral hemisphere can compensate for the damaged cortex by remodeling neuronal activity. Thus, clinical treatments specifically targeted to the ` intact'hemisphere following stroke may provide a complimentary strategy for promoting recovery of functional deficits and for improving quality of life in stroke patients.
学科主题	Neurosciences & Neurology
收录类别	SCI
WOS记录号	WOS:000337109400014
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/225206]
专题	中国科学院高能物理研究所
推荐引用方式 GB/T 7714	Jiang, XF,Zhang, T,Sy, C,et al. Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study[J]. NEUROLOGICAL RESEARCH,2014,36(SI5):475-482.
APA	Jiang, XF,Zhang, T,Sy, C,Nie, BB,Hu, XY,&Ding, YC；聂彬彬.(2014).Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study.NEUROLOGICAL RESEARCH,36(SI5),475-482.
MLA	Jiang, XF,et al."Dynamic metabolic changes after permanent cerebral ischemia in rats with/without post-stroke exercise: a positron emission tomography (PET) study".NEUROLOGICAL RESEARCH 36.SI5(2014):475-482.