Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

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	Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study
	Yin, Y; Jin, CF; Eyler, LT; Jin, H; Hu, XL; Duan, L; Zheng, HR; Feng, B; Huang, XY; Shan, BC
刊名	NEUROSCIENCE BULLETIN
	2012
卷号	28 期号:5 页码:541-549
关键词	functional magnetic resonance imaging post-traumatic stress disorder regional homogeneity resting-state
英文摘要	Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state. PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.
学科主题	Neurosciences & Neurology
收录类别	SCI
WOS记录号	WOS:000309357800009
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224010]
专题	高能物理研究所_核技术应用研究中心
推荐引用方式 GB/T 7714	Yin, Y,Jin, CF,Eyler, LT,et al. Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study[J]. NEUROSCIENCE BULLETIN,2012,28(5):541-549.
APA	Yin, Y.,Jin, CF.,Eyler, LT.,Jin, H.,Hu, XL.,...&Li, LJ；单保慈.(2012).Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study.NEUROSCIENCE BULLETIN,28(5),541-549.
MLA	Yin, Y,et al."Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study".NEUROSCIENCE BULLETIN 28.5(2012):541-549.