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	The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population
	Wei, QL; Diao, FC; Kang, Z; Gan, ZY; Han, ZL; Zheng, LR; Li, LJ; Guo, XF; Shan, BC; Liu, CL
刊名	NEUROSCIENCE LETTERS
	2012
卷号	517期号:1页码:21-24
关键词	DISC1 Schizophrenia Gray matter Magnetic resonance imaging
英文摘要	Schizophrenia is thought to arise in part from abnormal gray matter (GM), which are partly shared by the relatives of the probands. DISC1 is one of the most promising susceptibility genes of schizophrenia and a SNP rs821597 (A) in the gene was associated with schizophrenia in Han Chinese population. In this study, 61 healthy controls and 72 with schizophrenic patients were genotyped at rs821597, and underwent T1-weighted MRI for the density of GM. The results showed that the risk allele (A) carriers had higher GM density in regional left parahippocampal gyrus and right orbitofrontal cortex in schizophrenic patients, but had reduced GM density of these brain regions in healthy controls. The DISC1 variant rs821597 may confer risk for schizophrenia by its effects on the regional GM in left parahippocampal gyrus and right orbitofrontal cortex with other risk factors for schizophrenia. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
收录类别	SCI
WOS记录号	WOS:000304642500005
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/223765]
专题	高能物理研究所_核技术应用研究中心
推荐引用方式 GB/T 7714	Wei, QL,Diao, FC,Kang, Z,et al. The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population[J]. NEUROSCIENCE LETTERS,2012,517(1):21-24.
APA	Wei, QL.,Diao, FC.,Kang, Z.,Gan, ZY.,Han, ZL.,...&单保慈.(2012).The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.NEUROSCIENCE LETTERS,517(1),21-24.
MLA	Wei, QL,et al."The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population".NEUROSCIENCE LETTERS 517.1(2012):21-24.

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