Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging

	Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging
	Yu J(余杰); Yin WY(尹文艳); Zheng XP(郑晓鹏); Tian G(田甘); Zhang X(张潇); Bo T(薄涛); Dong XH(董兴华); Gu ZJ(谷战军); Zhao YL(赵宇亮); Yu, J
刊名	THERANOSTICS
	2015
卷号	5 期号:9 页码:931-945
关键词	Magnetic target Photothermal therapy Magnetic resonance imaging Photoacoustic tomography imaging Theranostic
通讯作者	尹文艳 ; 谷战军 ; 赵宇亮
英文摘要	The ability to selectively destroy cancer cells while sparing normal tissue is highly desirable during the cancer therapy. Here, magnetic targeted photothermal therapy was demonstrated by the integration of MoS2 (MS) flakes and Fe3O4 (IO) nanoparticles (NPs), where MoS2 converted near-infrared (NIR) light into heat and Fe3O4 NPs served as target moiety directed by external magnetic field to tumor site. The MoS2/Fe3O4 composite (MSIOs) functionalized by biocompatible polyethylene glycol (PEG) were prepared by a simple two-step hydrothermal method. And the as-obtained MSIOs exhibit high stability in bio-fluids and low toxicity in vitro and in vivo. Specifically, the MSIOs can be applied as a dual-modal probe for T-2-weighted magnetic resonance (MR) and photoacoustic tomography (PAT) imaging due to their superparamagnetic property and strong NIR absorption. Furthermore, we demonstrate an effective result for magnetically targeted photothermal ablation of cancer. All these results show a great potential for localized photothermal ablation of cancer spatially/timely guided by the magnetic field and indicated the promise of the multifunctional MSIOs for applications in cancer theranostics.
学科主题	Research & Experimental Medicine
类目[WOS]	Medicine, Research & Experimental
收录类别	SCI
WOS记录号	WOS:000359472200002
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228675]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Yu J,Yin WY,Zheng XP,et al. Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging[J]. THERANOSTICS,2015,5(9):931-945.
APA	余杰.,尹文艳.,郑晓鹏.,田甘.,张潇.,...&Zhao, YL.(2015).Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging.THERANOSTICS,5(9),931-945.
MLA	余杰,et al."Smart MoS2/Fe3O4 Nanotheranostic for Magnetically Targeted Photothermal Therapy Guided by Magnetic Resonance/Photoacoustic Imaging".THERANOSTICS 5.9(2015):931-945.