TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance

	TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance
	Tian G(田甘); Zheng XP(郑晓鹏); Zhang X(张潇); Yin WY(尹文艳); Yu J(于杰); Gu ZJ(谷战军); Zhao YL(赵宇亮); Tian, G; Zheng, XP; Zhang, X
刊名	BIOMATERIALS
	2015
卷号	40 页码:107-116
关键词	TPGS Upconversion nanoparticles P-gp inhibition Multi-drug resistance Theranostics
通讯作者	谷战军 ; 赵宇亮
英文摘要	Multi-drug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively investigated for overcoming MDR in cancer therapy because of its ability to inhibit P-glycoprotein (P-gp). In this work, TPGS was for the first time used as a new surface modifier to functionalize NaYbE4:Er upconversion nanoparticles (UNCPs) and endowed the as-prepared products (TPGS-UCNPs) with excellent water-solubility, P-gp inhibition capability and imaging-guided drug delivery property. After the chemotherapeutic drug (doxorubicin, DOX) loading, the as-formed composites (TPGS-UCNPs-DOX) exhibited potent killing ability for DOX-resistant MCF-7 cells. Flow-cytometric assessment and Western blot assay showed that the TPGS-UCNPs could potently decrease the P-gp expression and facilitate the intracellular drug accumulation, thus achieving MDR reversal. Moreover, considering that UCNPs process efficient upconversion emission and Yb element contained in UCNPs has strong X-ray attenuation ability, the as-obtained composite could also serve as a dual-modal probe for upconversion luminescence (UCL) imaging and X-ray computed tomography (CT) imaging, making them promising for imaging-guided cancer therapy. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Engineering; Materials Science
类目[WOS]	Engineering, Biomedical ; Materials Science, Biomaterials
收录类别	SCI ; EI
WOS记录号	WOS:000348963900012
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/228122]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Tian G,Zheng XP,Zhang X,et al. TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance[J]. BIOMATERIALS,2015,40:107-116.
APA	田甘.,郑晓鹏.,张潇.,尹文艳.,于杰.,...&Zhao, YL.(2015).TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance.BIOMATERIALS,40,107-116.
MLA	田甘,et al."TPGS-stabilized NaYbF4:Er upconversion nanoparticles for dual-modal fluorescent/CT imaging and anticancer drug delivery to overcome multi-drug resistance".BIOMATERIALS 40(2015):107-116.