Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles

	Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles
	Meng H(孟幻); Chen Z(陈真); Xing GM(邢更妹); Yuan H(袁慧); Chen CY(陈春英); Zhao F(赵峰); Zhang CC(张程程); Zhao YL(赵宇亮); Meng, H; Chen, Z
刊名	TOXICOLOGY LETTERS
	2007
卷号	175 期号:1-3 页码:#REF!
关键词	nanotoxicity ultrahigh reactivity copper metabolic alkalosis copper ion overload
通讯作者	Xing, GM (reprint author), Chinese Acad Sci, Inst High Energy Phys, Lab Bioenvironm Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China.
英文摘要	Recently, studies on the biological effects of nanomaterials show signs that some of the manufactured nanoparticles exhibit unexpected toxicity to living organisms. It has previously been reported that the copper particles possess size-depended toxicity. In this paper, we propose that the ultrahigh chemical reactivity of nano-copper results in the specific nanotoxicity which is fully proved by in vitro and in vivo experiment. Using chemical kinetics study (in vitro) and blood gas and plasma electrolytes analysis (in vivo), we found that high reactivity cause the big toxicological difference between small size (23.5 nm) and big size (17 mu m). The result is also consistent with biochemistry assay, pathological examination and copper content measurement in renal tissue in vivo. For chemical reactive nanoparticles, metallic nano-copper for instance, both the particles themselves and the resulting product (copper ion) should be fully explored. The nano-copper particles may not compromise the mice directly, however, they lead to the accumulation of excessive alkalescent substance and heavy metal ions (copper ions) culminating the metabolic alkalosis and copper ion overload. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
学科主题	Toxicology
类目[WOS]	Toxicology
收录类别	SCI
WOS记录号	WOS:000251696900012
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/226158]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Meng H,Chen Z,Xing GM,et al. Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles[J]. TOXICOLOGY LETTERS,2007,175(1-3):#REF!.
APA	孟幻.,陈真.,邢更妹.,袁慧.,陈春英.,...&Zhao, YL.(2007).Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles.TOXICOLOGY LETTERS,175(1-3),#REF!.
MLA	孟幻,et al."Ultrahigh reactivity provokes nanotoxicity: Explanation of oral toxicity of nano-copper particles".TOXICOLOGY LETTERS 175.1-3(2007):#REF!.