WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells

	WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells
	Yong Y(雍媛); Zhou LJ(周亮君); Gu ZJ(谷战军); Yong, Y; Zhou, LJ; Gu, ZJ; Yan, L; Tian, G; Zheng, XP; Liu, XD
刊名	NANOSCALE
	2014
卷号	6 期号:17 页码:10394-10403
英文摘要	We have developed a simple and efficient strategy to fabricate WS2 nanosheets with low toxicity and good water solubility via a liquid exfoliation method by using H2SO4 intercalation and ultrasonication. The as-prepared WS2 nanosheets were employed not only as an NIR absorbing agent for photothermal therapy (PTT) but also as a photosensitizer (PS) carrier for photodynamic therapy (PDT) due to their sheet like structure that offers large surface area to load PS molecules. Moreover, singlet-oxygen generation of the PSs-WS2 complex could be finely controlled by NIR irradiation that could manipulate the PSs release behavior from WS2 nanosheets. The synergistic anti-tumor effect of WS2 nanosheets mediated PDT-PTT was also evaluated carefully and the results clearly showed that the efficacy of combined PDT-PTT treatment of cancer cells is significantly higher than those of PDT-only and PTT-only treatment, indicating enhanced efficiency of the combined therapeutic system. In addition, the WS2 could be used as a computed tomography (CT) contrast agent for bio-imaging since W atoms have strong X-ray attenuation ability, making them a multifunctional theranostic platform for simultaneous imaging-guided diagnosis and therapy.
学科主题	Chemistry; Science & Technology - Other Topics; Materials Science; Physics
收录类别	SCI
WOS记录号	WOS:000340520500063
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/225199]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Yong Y,Zhou LJ,Gu ZJ,et al. WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells[J]. NANOSCALE,2014,6(17):10394-10403.
APA	雍媛.,周亮君.,谷战军.,Yong, Y.,Zhou, LJ.,...&赵宇亮.(2014).WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells.NANOSCALE,6(17),10394-10403.
MLA	雍媛,et al."WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells".NANOSCALE 6.17(2014):10394-10403.