Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging

	Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging
	Zhou LJ(周亮君); Zheng XP(郑晓鹏); Gu ZJ(谷战军); Zhou, LJ; Zheng, XP; Gu, ZJ; Yin, WY; Zhang, X; Ruan, LF; Yang, YB
刊名	BIOMATERIALS
	2014
卷号	35 期号:26 页码:7666-7678
关键词	Mesoporous Core-shell Up-conversion nanoparticles Targeted drug delivery Multimodality biomedical imaging
英文摘要	We developed a facile strategy to obtain a new kind of mesoporous core-shell structured up-conversion nanoparticles (mUCNPs), composed of a NaYbF4:2%Er core and a mesoporous NaGdF4 shell. This mesoporous shell not only enhanced the up-conversion luminescence but also endowed many other functionalities of the nanoparticles such as drug delivery and bio-imaging capabilities. Moreover, after being conjugated with polyethylenimine (PEI) and folic acid (FA), core-shell mUCNPs exhibited good water dispersibility, enhanced drug delivery efficiency, and remarkable targeting ability to cancer cells. To certify the folate receptors (FR)-mediated targeted drug delivery, cell viability assay, cell up-conversion luminescence imaging and flow cytometry analysis were carried out. Furthermore, apart from the application for targeted drug delivery, the as-prepared core-shell mUCNPs could also be employed as the contrast agents for X-ray computed tomography (CT) and magnetic resonance (MR) imaging, because of the strong X-ray attenuation ability of Yb and high longitudinal molar relaxivity (r(1)) of Gd in the nanoparticles, providing the potential for simultaneously bio-imaging and cancer-targeting therapy. (C) 2014 Elsevier Ltd. All rights reserved.
学科主题	Engineering; Materials Science
收录类别	SCI
WOS记录号	WOS:000339035000039
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224861]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Zhou LJ,Zheng XP,Gu ZJ,et al. Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging[J]. BIOMATERIALS,2014,35(26):7666-7678.
APA	周亮君.,郑晓鹏.,谷战军.,Zhou, LJ.,Zheng, XP.,...&赵宇亮.(2014).Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging.BIOMATERIALS,35(26),7666-7678.
MLA	周亮君,et al."Mesoporous NaYbF4@NaGdF4 core-shell up-conversion nanoparticles for targeted drug delivery and multimodal imaging".BIOMATERIALS 35.26(2014):7666-7678.