Understanding the Toxicity of Carbon Nanotubes

	Understanding the Toxicity of Carbon Nanotubes
	Liu, Y; Zhao YL(赵宇亮); 孙宝云; Zhao, YL; Sun, BY; Chen, CY
刊名	ACCOUNTS OF CHEMICAL RESEARCH
	2013
卷号	46 期号:3 页码:702-713
英文摘要	Because of their unique physical, chemical, electrical, and mechanical properties, carbon nanotubes (CNTs) have attracted a great deal of research interest and have many potential applications. As large-scale production and application of CNTs increases, the general population is more likely to be exposed to CNTs either directly or indirectly, which has prompted considerable attention about human health and safety issues related to CNTs. Although considerable experimental data related to CNT toxicity at the molecular, cellular, and whole animal levels have been published, the results are often conflicting. Therefore, a systematic understanding of CNT toxicity is needed but has not yet been developed. In this Account, we highlight recent investigations into the basis of CNT toxicity carried out by our team and by other laboratories. We focus on several important factors that explain the disparities in the experimental results of nanotoxicity, such as impurities, amorphous carbon, surface charge, shape, length, agglomeration, and layer numbers. The exposure routes, including inhalation, intravenous injection, or dermal or oral exposure, can also influence the in vivo behavior and fate of CNTs. The underlying mechanisms of CNT toxicity include oxidative stress, inflammatory responses, malignant transformation, DNA damage and mutation (errors in chromosome number as well as disruption of the mitotic spindle), the formation of granulomas, and interstitial fibrosis. These findings provide useful insights for de novo design and safe application of carbon nanotubes and their risk assessment to human health. To obtain reproducible and accurate results, researchers must establish standards and reliable detection methods, use standard CNT samples as a reference control, and study the impact of various factors systematically. In addition, researchers need to examine multiple types of CNTs, different cell lines and animal species, multidimensional evaluation methods, and exposure conditions. To make results comparable among different institutions and countries, researchers need to standardize choices in toxicity testing such as that of cell line, animal species, and exposure conditions. The knowledge presented here should lead to a better understanding of the key factors that can influence CNT toxicity so that their unwanted toxicity might be avoided.
学科主题	Chemistry
收录类别	SCI
WOS记录号	WOS:000317317200011
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ihep.ac.cn/handle/311005/224042]
专题	高能物理研究所_多学科研究中心
推荐引用方式 GB/T 7714	Liu, Y,Zhao YL,孙宝云； Zhao, YL,et al. Understanding the Toxicity of Carbon Nanotubes[J]. ACCOUNTS OF CHEMICAL RESEARCH,2013,46(3):702-713.
APA	Liu, Y,赵宇亮,孙宝云； Zhao, YL,Sun, BY,&Chen, CY.(2013).Understanding the Toxicity of Carbon Nanotubes.ACCOUNTS OF CHEMICAL RESEARCH,46(3),702-713.
MLA	Liu, Y,et al."Understanding the Toxicity of Carbon Nanotubes".ACCOUNTS OF CHEMICAL RESEARCH 46.3(2013):702-713.