Synthesis of functionalized fluorescent gold nanoclusters for acid phosphatase sensing

	Synthesis of functionalized fluorescent gold nanoclusters for acid phosphatase sensing
	Sun,Jian; Yang,Fan; Yang,Xiurong
刊名	nanoscale
	2015
卷号	7 期号:39 页码:16372-16380
关键词	GRAPHENE QUANTUM DOTS ONE-POT SYNTHESIS ALKALINE-PHOSPHATASE PROSTATE-CANCER CONJUGATED POLYELECTROLYTE CONTAINING METABOLITES SELECTIVE DETECTION METAL NANOCLUSTERS FACILE SYNTHESIS AQUEOUS-MEDIA
通讯作者	yang,xr
英文摘要	a novel and convenient one-pot but two-step synthesis of fluorescent gold nanoclusters, incorporating glutathione (gsh) and 11-mercaptoundecanoic acid (mua) as the functionalized ligands (i.e. auncs@gsh/mua), is demonstrated. herein, the mixing of haucl4 and gsh in aqueous solution results in the immediate formation of non-fluorescent gsh-au+ complexes, and then a class of similar to 2.6 nm gsh-coated auncs (auncs@gsh) with mild orange-yellow fluorescence after several days. interestingly, the intense orange-red emitting similar to 1.7 nm auncs@gsh/mua can be synthesized within seconds by introducing an alkaline aqueous solution of mua into the gsh-au+ complexes or aunc@gsh solution. subsequently, a reliable aunc@gsh/mua-based real-time assay of acid phosphatase (acp) is established for the first time, inspired by the selective coordination of fe3+ with surface ligands of auncs, the higher binding affinity between the pyrophosphate ion (ppi) and fe3+, and the hydrolysis of ppi into orthophosphate by acp. our fluorescent chemosensor can also be applied to assay acp in a real biological sample and, furthermore, to screen the inhibitor of acp. this report paves a new avenue for synthesizing auncs based on either the bottom-up reduction or top-down etching method, establishing real-time fluorescence assays for acp by means of ppi as the substrate, and further exploring the sensing applications of fluorescent auncs.
收录类别	SCI
语种	英语
WOS记录号	WOS:000362350700030
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64678]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Sun,Jian,Yang,Fan,Yang,Xiurong. Synthesis of functionalized fluorescent gold nanoclusters for acid phosphatase sensing[J]. nanoscale,2015,7(39):16372-16380.
APA	Sun,Jian,Yang,Fan,&Yang,Xiurong.(2015).Synthesis of functionalized fluorescent gold nanoclusters for acid phosphatase sensing.nanoscale,7(39),16372-16380.
MLA	Sun,Jian,et al."Synthesis of functionalized fluorescent gold nanoclusters for acid phosphatase sensing".nanoscale 7.39(2015):16372-16380.