Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment

	Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment
	Chen,Yinyin; Liu,Bei; Deng,Xiaoran; Huang,Shanshan; Hou,Zhiyao; Li,Chunxia; Lin,Jun
刊名	nanoscale
	2015
卷号	7 期号:18 页码:8574-8583
关键词	MESOPOROUS SILICA NANOPARTICLES CONTROLLED DRUG-DELIVERY IN-VIVO CANCER-THERAPY CELLS NANOSTRUCTURES TOXICITY
通讯作者	li,cx
英文摘要	core-shell structured nd3+-sensitized nayf4:yb/nd/er@nayf4:nd@msio(2) nanoparticles (nps) were designed and synthesized. the nayf4:yb/nd/er@nayf4:nd core imparts the nanomaterials with luminescence properties for upconversion optical imaging under 808 nm laser irradiation, whereas the mesoporous sio2 shell allows the nanomaterials to be loaded with anticancer drug doxorubicin (dox). in vivo toxicity assessment has confirmed that the nps have low systematic toxicity in healthy mice. in vivo antitumor activity shows that the nanocomposites exhibit greater antitumor efficacy than pure dox. as a result, the composite nanomaterials can serve as nanotheranostic materials for synchronous upconversion luminescence imaging under 808 nm laser irradiation, and as anticancer drug delivery vehicles, so as to integrate the diagnosis and treatment of cancers in vivo.
收录类别	SCI
语种	英语
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64666]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Chen,Yinyin,Liu,Bei,Deng,Xiaoran,et al. Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment[J]. nanoscale,2015,7(18):8574-8583.
APA	Chen,Yinyin.,Liu,Bei.,Deng,Xiaoran.,Huang,Shanshan.,Hou,Zhiyao.,...&Lin,Jun.(2015).Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment.nanoscale,7(18),8574-8583.
MLA	Chen,Yinyin,et al."Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment".nanoscale 7.18(2015):8574-8583.