Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic

	Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic
	Xu,Weiguo; Ding,Jianxun; Xiao,Chunsheng; Li,Lingyu; Zhuang,Xiuli; Chen,Xuesi
刊名	biomaterials
	2015
卷号	54 期号:1 页码:72-86
关键词	DRUG-DELIVERY TARGETED DELIVERY BLOCK-COPOLYMERS TUMOR-CELLS CANCER PH NANOPARTICLES CISPLATIN TOXICITY CHEMOTHERAPY
通讯作者	ding,jx
英文摘要	recently, chemotherapy has been one of the most important therapeutic approaches for malignant tumors. the tumor tissular or intracellular microenvironment-sensitive polymer-doxorubicin (dox) conjugates demonstrate great potential for improved antitumor efficacy and reduced side effects. in this work, the acid-sensitive dextran-dox conjugate (noted as dex-o-dox) was synthesized through the versatile efficient oximation reaction between the terminal aldehyde group of polysaccharide and the amino group in dox in the buffer solution of sodium acetate/acetic acid. the insensitive one, i.e., dex-b-dox, was prepared similarly as dex-o-dox with a supplemented reduction reaction. the dox release from dex-o-dox was ph-dependent and accelerated by the decreased ph. the efficient intracellular dox release from dex-o-dox toward the human hepatoma hepg2 cells was further confirmed. furthermore, dex-o-dox exhibited a closer antiproliferative activity to free dox center dot hcl as the extension of time. more importantly, compared with dex-b-dox, dex-o-dox exhibited higher antitumor activity and lower toxicity, which were further confirmed by the systemic histological and immunohistochemical analyses. hence, the facilely prepared smart polysaccharide-dox conjugates, i.e., dex-o-dox, exhibited great potential in the clinical chemotherapy of malignancy. (c) 2015 elsevier ltd. all rights reserved.
收录类别	SCI
语种	英语
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64588]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Xu,Weiguo,Ding,Jianxun,Xiao,Chunsheng,et al. Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic[J]. biomaterials,2015,54(1):72-86.
APA	Xu,Weiguo,Ding,Jianxun,Xiao,Chunsheng,Li,Lingyu,Zhuang,Xiuli,&Chen,Xuesi.(2015).Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic.biomaterials,54(1),72-86.
MLA	Xu,Weiguo,et al."Versatile preparation of intracellular-acidity-sensitive oxime-linked polysaccharide-doxorubicin conjugate for malignancy therapeutic".biomaterials 54.1(2015):72-86.