Poly(Acrylic Acid) Modification of Nd3+-Sensitized Upconversion Nanophosphors for Highly Efficient UCL Imaging and pH-Responsive Drug Delivery

	Poly(Acrylic Acid) Modification of Nd3+-Sensitized Upconversion Nanophosphors for Highly Efficient UCL Imaging and pH-Responsive Drug Delivery
	Liu,Bei; Chen,Yinyin; Li,Chunxia; He,Fei; Hou,Zhiyao; Huang,Shanshan; Zhu,Haomiao; Chen,Xueyuan; Lin,Jun
刊名	advanced functional materials
	2015
卷号	25 期号:29 页码:4717-4729
关键词	CORE-SHELL NANOSTRUCTURES NEAR-INFRARED LIGHT 800 NM PHOTODYNAMIC THERAPY OPTICAL-PROPERTIES BIOIMAGING PROBES NANOPARTICLES LUMINESCENT FABRICATION NANOCRYSTALS
通讯作者	liu,b
英文摘要	in this work, a simple method is demonstrated for the synthesis of multifunctional core-shell nanoparticles nayf4:yb,er@nayf4:yb@nandf4:yb@nayf4:yb@paa (labeled as er@y@nd@y@paa or ucnp@paa), which contain a highly effective 808-nm-to-visible ucnp core and a thin shell of poly(acrylic acid) (paa) to achieve upconversion bioimaging and ph-sensitive anticancer chemotherapy simultaneously. the core-shell nd3+-sensitized ucnps are optimized by varying the shell number, core size, and host lattices. the final optimized er@y@nd@y nanoparticle composition shows a significantly improved upconversion luminescence intensity, that is, 12.8 times higher than er@y@nd nanoparticles. after coating the nanocomposites with a thin layer of paa, the resulting ucnp@paa nanocomposite perform well as a ph-responsive nanocarrier and show clear advantages over ucnp@msio(2), which are evidenced by in vitro/in vivo experiments. histological analysis also reveals that no pathological changes or inflammatory responses occur in the heart, lungs, kidneys, liver, and spleen. in summary, this study presents a major step forward towards a new therapeutic and diagnostic treatment of tumors by using 808-nm excited ucnps to replace the traditional 980-nm excitation.
收录类别	SCI
语种	英语
WOS记录号	WOS:000359025700018
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64543]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Liu,Bei,Chen,Yinyin,Li,Chunxia,et al. Poly(Acrylic Acid) Modification of Nd3+-Sensitized Upconversion Nanophosphors for Highly Efficient UCL Imaging and pH-Responsive Drug Delivery[J]. advanced functional materials,2015,25(29):4717-4729.
APA	Liu,Bei.,Chen,Yinyin.,Li,Chunxia.,He,Fei.,Hou,Zhiyao.,...&Lin,Jun.(2015).Poly(Acrylic Acid) Modification of Nd3+-Sensitized Upconversion Nanophosphors for Highly Efficient UCL Imaging and pH-Responsive Drug Delivery.advanced functional materials,25(29),4717-4729.
MLA	Liu,Bei,et al."Poly(Acrylic Acid) Modification of Nd3+-Sensitized Upconversion Nanophosphors for Highly Efficient UCL Imaging and pH-Responsive Drug Delivery".advanced functional materials 25.29(2015):4717-4729.