Cancer biomarker detection: recent achievements and challenges

	Cancer biomarker detection: recent achievements and challenges
	Wu,Li,Qu,Xiaogang
刊名	chemical society reviews
	2015
卷号	44 期号:10 页码:2963-2997
关键词	CIRCULATING TUMOR-CELLS ENHANCED RAMAN-SCATTERING PROSTATE-SPECIFIC ANTIGEN ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY LINKED-IMMUNOSORBENT-ASSAY SURFACE-PLASMON RESONANCE HUMAN TELOMERASE ACTIVITY REAL-TIME DETECTION HIGHLY SENSITIVE DETECTION DUPLEX-SPECIFIC NUCLEASE
通讯作者	qu,xg
英文摘要	the early detection of cancer can significantly reduce cancer mortality and saves lives. thus, a great deal of effort has been devoted to the exploration of new technologies to detect early signs of the disease. cancer biomarkers cover a broad range of biochemical entities, such as nucleic acids, proteins, sugars, small metabolites, and cytogenetic and cytokinetic parameters, as well as entire tumour cells found in the body fluid. they can be used for risk assessment, diagnosis, prognosis, and for the prediction of treatment efficacy and toxicity and recurrence. in this review, we provide an overview of recent advances in cancer biomarker detection. several representative examples using different approaches for each biomarker have been reviewed, and all these cases demonstrate that the multidisciplinary technology-based cancer diagnostics are becoming an increasingly relevant alternative to traditional techniques. in addition, we also discuss the unsolved problems and future challenges in the evaluation of cancer biomarkers. clearly, solving these hurdles requires great effort and collaboration from different communities of chemists, physicists, biologists, clinicians, material-scientists, and engineering and technical researchers. a successful outcome will result in the realization of point-of-care diagnosis and individualized treatment of cancers by non-invasive and convenient tests in the future.
收录类别	SCI
语种	英语
公开日期	2016-05-03
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/64501]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wu,Li,Qu,Xiaogang. Cancer biomarker detection: recent achievements and challenges[J]. chemical society reviews,2015,44(10):2963-2997.
APA	Wu,Li,Qu,Xiaogang.(2015).Cancer biomarker detection: recent achievements and challenges.chemical society reviews,44(10),2963-2997.
MLA	Wu,Li,Qu,Xiaogang."Cancer biomarker detection: recent achievements and challenges".chemical society reviews 44.10(2015):2963-2997.