Tissue Metabonomic Phenotyping for Diagnosis and Prognosis of Human Colorectal Cancer

CORC > 武汉物理与数学研究所 > 中国科学院武汉物理与数学研究所 > 磁共振应用研究部

	Tissue Metabonomic Phenotyping for Diagnosis and Prognosis of Human Colorectal Cancer
	Tian, Yuan 1; Xu, Tangpeng 3,4; Huang, Jia 3,5; Zhang, Limin 1; Xu, Shan 1; Xiong, Bin 3; Wang, Yulan 1,6; Tang, Huiru 1,2
刊名	SCIENTIFIC REPORTS
	2016-02-15
卷号	6
英文摘要	Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide and prognosis based on the conventional histological grading method for CRC remains poor. To better the situation, we analyzed the metabonomic signatures of 50 human CRC tissues and their adjacent non-involved tissues (ANIT) using high-resolution magic-angle spinning (HRMAS) H-1 NMR spectroscopy together with the fatty acid compositions of these tissues using GC-FID/MS. We showed that tissue metabolic phenotypes not only discriminated CRC tissues from ANIT, but also distinguished low-grade tumor tissues (stages I-II) from the high-grade ones (stages III-IV) with high sensitivity and specificity in both cases. Metabonomic phenotypes of CRC tissues differed significantly from that of ANIT in energy metabolism, membrane biosynthesis and degradations, osmotic regulations together with the metabolism of proteins and nucleotides. Amongst all CRC tissues, the stage I tumors exhibited largest differentiations from ANIT. The combination of the differentiating metabolites showed outstanding collective power for differentiating cancer from ANIT and for distinguishing CRC tissues at different stages. These findings revealed details in the typical metabonomic phenotypes associated with CRC tissues nondestructively and demonstrated tissue metabonomic phenotyping as an important molecular pathology tool for diagnosis and prognosis of cancerous solid tumors.
WOS标题词	Science & Technology
类目[WOS]	Multidisciplinary Sciences
研究领域[WOS]	Science & Technology - Other Topics
关键词[WOS]	DIHYDROPYRIMIDINE DEHYDROGENASE ; REVEALS ALTERATIONS ; PROSTATE-CANCER ; BIOMARKERS ; CARCINOMA ; PROTEOME ; CELLS ; SPECTROSCOPY ; METABOLOMICS ; CHEMOTHERAPY
收录类别	SCI
语种	英语
WOS记录号	WOS:000370036200001
公开日期	2016-04-26
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/9190]
专题	武汉物理与数学研究所_磁共振应用研究部
作者单位	1.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, Wuhan Inst Phys & Math,CAS Key Lab Magnet Resonan, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 2.Fudan Univ, Sch Life Sci,Minist Educ, Collaborat Innovat Ctr Genet & Dev,State Key Lab, Metabon & Syst Biol Lab,Key Lab Contemporary Anth, Shanghai 200438, Peoples R China 3.Wuhan Univ, Zhongnan Hosp, Dept Oncol, Wuhan 430071, Peoples R China 4.Wuhan Univ, Renmin Hosp, Dept Oncol, Wuhan 430071, Peoples R China 5.China Japan Friendship Hosp, Dept Hepatobiliary Surg, Beijing 100029, Peoples R China 6.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Tian, Yuan,Xu, Tangpeng,Huang, Jia,et al. Tissue Metabonomic Phenotyping for Diagnosis and Prognosis of Human Colorectal Cancer[J]. SCIENTIFIC REPORTS,2016,6.
APA	Tian, Yuan.,Xu, Tangpeng.,Huang, Jia.,Zhang, Limin.,Xu, Shan.,...&Tang, Huiru.(2016).Tissue Metabonomic Phenotyping for Diagnosis and Prognosis of Human Colorectal Cancer.SCIENTIFIC REPORTS,6.
MLA	Tian, Yuan,et al."Tissue Metabonomic Phenotyping for Diagnosis and Prognosis of Human Colorectal Cancer".SCIENTIFIC REPORTS 6(2016).