The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals
	Tian, Jijing; Feng, Yu; Fu, Hualing; Xie, Heidi Qunhui; Jiang, Joy Xiaosong; Zhao, Bin
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY
	2015-08-18
卷号	49 期号:16 页码:9518-9531
英文摘要	The aryl hydrocarbon receptor (AhR) is a highly evolutionary conserved, ligand-activated transcription factor that is best known to mediate the toxicities of dioxins and dioxin-like compounds. Phenotype of AhR-null mice, together with the recent discovery of a variety of endogenous and plant-derived ligands, point to the integral roles of AhR in normal cell physiology, in addition to its roles in sensing the environmental chemicals. Here, we summarize the current knowledge about AhR signaling pathways, its ligands and AhR-mediated effects on cell specialization, host defense and detoxification. AhR-mediated health effects particularly in liver, immune, and nervous systems, as well as in tumorgenesis are discussed. Dioxin-initiated embryotoxicity and immunosuppressive effects in fish and birds are reviewed. Recent data demonstrate that AhR is a convergence point of multiple signaling pathways that inform the cell of its external and internal environments. As such, AhR pathway is a promising potential target for therapeutics targeting nervous, liver, and autoimmune diseases through AhR ligand-mediated interventions and other perturbations of AhR signaling. Additionally, using available laboratory data obtained on animal models, AhR-centered adverse outcome pathway analysis is useful in reexamining known and potential adverse outcomes of specific or mixed compounds on wildlife.
研究领域[WOS]	Engineering, Environmental ; Environmental Sciences
WOS记录号	WOS:000359891700018
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/32682]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Tian, Jijing,Feng, Yu,Fu, Hualing,et al. The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2015,49(16):9518-9531.
APA	Tian, Jijing,Feng, Yu,Fu, Hualing,Xie, Heidi Qunhui,Jiang, Joy Xiaosong,&Zhao, Bin.(2015).The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals.ENVIRONMENTAL SCIENCE & TECHNOLOGY,49(16),9518-9531.
MLA	Tian, Jijing,et al."The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals".ENVIRONMENTAL SCIENCE & TECHNOLOGY 49.16(2015):9518-9531.