Synthesis and Biological Activities of 5-Thio-alpha-GalCers

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Synthesis and Biological Activities of 5-Thio-alpha-GalCers
	Bi, Jingjing; Wang, Jing; Zhou, Kai; Wang, Yuancheng; Fang, Min; Du, Yuguo
刊名	ACS MEDICINAL CHEMISTRY LETTERS
	2015-04
卷号	6 期号:4 页码:476-480
关键词	KRN7000 5-thio-alpha-GalCer iNKT cells antitumor activity
英文摘要	NKT cells, a unique subset of T cells that recognizes glycolipid antigens presented by CD1d molecules, are believed to produce key cytokines of both Th1 and Th2 T cells and are thus involved in the control of several types of immune response. As an active glycolipid antigen having alpha-galactosyl ceramide core structure, KRN7000 showed promising immunostimulation activity and was selected as an anticancer drug candidate for further clinical application. In this report, three new KRN7000 structural analogues were designed and synthesized, in which the ring oxygen of the galactopyranose residue is replaced by a sulfur atom along with the variation on the lipid chain. Their abilities for stimulating mouse NKT cells to produce IFN-gamma and IL-4 were evaluated both in vivo and in vitro.
研究领域[WOS]	Chemistry, Medicinal
WOS记录号	WOS:000353098300021
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/32676]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Bi, Jingjing,Wang, Jing,Zhou, Kai,et al. Synthesis and Biological Activities of 5-Thio-alpha-GalCers[J]. ACS MEDICINAL CHEMISTRY LETTERS,2015,6(4):476-480.
APA	Bi, Jingjing,Wang, Jing,Zhou, Kai,Wang, Yuancheng,Fang, Min,&Du, Yuguo.(2015).Synthesis and Biological Activities of 5-Thio-alpha-GalCers.ACS MEDICINAL CHEMISTRY LETTERS,6(4),476-480.
MLA	Bi, Jingjing,et al."Synthesis and Biological Activities of 5-Thio-alpha-GalCers".ACS MEDICINAL CHEMISTRY LETTERS 6.4(2015):476-480.