A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290
	Li, Xin1,2 ; Li, Xiao-Ming 1; Zhang, Peng1,2 ; Wang, Bin-Gui1
刊名	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
	2015-12-02
卷号	17 期号:12 页码:1204-1212
关键词	Marine alga-derived fungus Penicillium oxalicum secondary metabolites antibacterial activity anti-HAB activity
英文摘要	Ten secondary metabolites (1-10) including a new phenolic enamide, methyl (Z)-3-(3,4-dihydroxyphenyl)-2-formamidoacrylate (1), and a new meroterpenoid, 15-hydroxydecaturin A (2), were characterized from the EtOAc extracts of the marine alga-derived endophytic fungus Penicillium oxalicum EN-290. The structures of these compounds were elucidated on the basis of 1D and 2D NMR experiments and the absolute configuration of compound 2 was confirmed by electronic circular dichroism quantum calculations. Compound 1 showed potent activity against Staphylococcus aureus with an MIC value of 2.0g/ml, which is stronger than that of the positive control (chloromycetin, with an MIC 4.0g/ml). This compound also showed activity against harmful algal bloom causative species Nitzschia closterium with inhibition zones of 20, 16, and 10mm at 20, 10, and 5mg/ml, respectively. Interestingly, so far, this type of anti-HAB metabolites has only been found in the algal-derived isolate of P. oxalicum. It could probably be a defense of this fungus against environmental stress and threat of survival.
收录类别	SCI
语种	英语
WOS记录号	WOS:000368454000012
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/95225]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Univ Chinese Acad Sci, Coll Earth Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Xin,Li, Xiao-Ming,Zhang, Peng,et al. A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2015,17(12):1204-1212.
APA	Li, Xin,Li, Xiao-Ming,Zhang, Peng,&Wang, Bin-Gui.(2015).A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,17(12),1204-1212.
MLA	Li, Xin,et al."A new phenolic enamide and a new meroterpenoid from marine alga-derived endophytic fungus Penicillium oxalicum EN-290".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 17.12(2015):1204-1212.