Role of autophagy in the pathogenesis of multiple sclerosis

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	Role of autophagy in the pathogenesis of multiple sclerosis
	Liang, PZ; Le, WD
刊名	NEUROSCIENCE BULLETIN
	2015
卷号	31 期号:4 页码:435-444
关键词	EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS CENTRAL-NERVOUS-SYSTEM ANTIGEN-PRESENTING CELLS FOCAL CEREBRAL-ISCHEMIA T-CELLS MTOR KINASE GENE ATG5 NEURODEGENERATIVE DISEASE IL-1-BETA PRODUCTION AXON REGENERATION
通讯作者	Le, WD (reprint author), Dalian Med Univ, Liated Hosp 1, Ctr Translat Res Neurol Dis, Dalian 116011, Peoples R China.,wdle@sibs.ac.cn
英文摘要	Autophagy plays an important role in maintaining the cellular homeostasis. One of its functions is to degrade unnecessary organelles and proteins for energy recycling or amino-acids for cell survival. Ablation of autophagy leads to neurodegeneration. Multiple sclerosis (MS), a permanent neurological impairment typical of chronic inflammatory demyelinating disorder, is an auto-immune disease of the central nervous system (CNS). Autophagy is tightly linked to the innate and adaptive immune systems during the autoimmune process, and several studies have shown that autophagy directly participates in the progress of MS or experimental autoimmune encephalomyelitis (EAE, a mouse model of MS). Dysfunction of mitochondria that intensively influences the autophagy pathway is one of the important factors in the pathogenesis of MS. Autophagy-related gene (ATG) 5 and immune-related GTPase M (IRGM) 1 are increased, while ATG16L2 is decreased, in T-cells in EAE and active relapsing-remitting MS brains. Administration of rapamycin, an inhibitor of mammalian target of rapamycin (mTOR), ameliorates relapsing-remitting EAE. Inflammation and oxidative stress are increased in MS lesions and EAE, but Lamp2 and the LC3-II/LC3-I ratio are decreased. Furthermore, autophagy in various glial cells plays important roles in regulating neuro-inflammation in the CNS, implying potential roles in MS. In this review, we discuss the role of autophagy in the peripheral immune system and the CNS in neuroinflammation associated with the pathogenesis of MS.
学科主题	Neurosciences
WOS标题词	Neurosciences & Neurology
收录类别	SCI
语种	英语
WOS记录号	WOS:000361452400007
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/3937]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Liang, PZ,Le, WD. Role of autophagy in the pathogenesis of multiple sclerosis[J]. NEUROSCIENCE BULLETIN,2015,31(4):435-444.
APA	Liang, PZ,&Le, WD.(2015).Role of autophagy in the pathogenesis of multiple sclerosis.NEUROSCIENCE BULLETIN,31(4),435-444.
MLA	Liang, PZ,et al."Role of autophagy in the pathogenesis of multiple sclerosis".NEUROSCIENCE BULLETIN 31.4(2015):435-444.