Ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse

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	Ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse
	Yang, QQ; Liu, SX; Yin, M; Yin, YQ; Zhou, GM; Zhou, JW
刊名	DEVELOPMENTAL NEUROBIOLOGY
	2015
卷号	75 期号:11 页码:1282-1294
关键词	B-CELL FACTORS TRANSCRIPTION FACTOR SUBSTANTIA-NIGRA RAT MIDBRAIN BRAIN-STEM DIFFERENTIATION FAMILY GENES EXPRESSION MICE
通讯作者	Zhou, JW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Dev & Degenerat Basal Ganglia,Inst Neurosci, Ctr Excellence Brain Sci,State Key Lab Neurosci, Shanghai 200031, Peoples R China.,gmzhou@shmu.edu.cn
英文摘要	Dopaminergic (DA) neurons in the midbrain ventral periaqueductal gray matter (PAG) play critical roles in various physiological and pathophysiological processes including sleep-wake rhyme, antinociception, and drug addiction. However, the molecular mechanisms underlying their development are poorly understood. Here, we showed that PAG DA neurons arose as early as E15.5 in mouse embryos. During the prenatal period, the majority of PAG DA neurons was distributed in the intermediate and caudal regions of the PAG. In the postnatal brain, approximate to 50% of PAG DA neurons were preferentially located in the caudal portion of the PAG. Moreover, transcription factor early B-cell factor 2 (Ebf2) was transiently expressed in a subset of DA neurons in embryonic ventral mesencephalon. Functional analysis revealed that loss of Ebf2 in vivo caused a marked reduction in the number of DA neurons in the midbrain PAG but not in the substantia nigra and ventral tegmental area. Thus, Ebf2 is identified as a novel and important regulator selectively required for midbrain PAG DA neuron development. (c) 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 1282-1294, 2015
学科主题	Developmental Biology ; Neurosciences
WOS标题词	Developmental Biology ; Neurosciences & Neurology
收录类别	SCI
语种	英语
WOS记录号	WOS:000362839200009
公开日期	2016-02-26
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/3927]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yang, QQ,Liu, SX,Yin, M,et al. Ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse[J]. DEVELOPMENTAL NEUROBIOLOGY,2015,75(11):1282-1294.
APA	Yang, QQ,Liu, SX,Yin, M,Yin, YQ,Zhou, GM,&Zhou, JW.(2015).Ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse.DEVELOPMENTAL NEUROBIOLOGY,75(11),1282-1294.
MLA	Yang, QQ,et al."Ebf2 is required for development of dopamine neurons in the midbrain periaqueductal gray matter of mouse".DEVELOPMENTAL NEUROBIOLOGY 75.11(2015):1282-1294.